The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless - PubMed (original) (raw)
Comparative Study
The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
F Rijsewijk et al. Cell. 1987.
Abstract
We have isolated the Drosophila melanogaster homolog (Dint-1) of int-1, a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains 468 amino acids and starts with a hydrophobic leader; it is 54% identical to the int-1 sequence, and all 23 cysteine residues are conserved. The putative Drosophila protein has an extra sequence of 85 amino acids, encoded on an additional exon. Dint-1 is expressed throughout development, but transcripts are barely detectable in adult flies. Hybridization in situ to embryos reveals a segmented pattern of expression. We show that Dint-1 and the segment polarity gene wingless are identical and map to the same location. The sequence of the gene suggests that the Dint-1/wingless protein functions in morphogenesis as a signal in cell-cell communication.
Similar articles
- Phenocopies induced with antisense RNA identify the wingless gene.
Cabrera CV, Alonso MC, Johnston P, Phillips RG, Lawrence PA. Cabrera CV, et al. Cell. 1987 Aug 14;50(4):659-63. doi: 10.1016/0092-8674(87)90039-0. Cell. 1987. PMID: 2440586 - Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless.
Wainwright BJ, Scambler PJ, Stanier P, Watson EK, Bell G, Wicking C, Estivill X, Courtney M, Boue A, Pedersen PS, et al. Wainwright BJ, et al. EMBO J. 1988 Jun;7(6):1743-8. doi: 10.1002/j.1460-2075.1988.tb03003.x. EMBO J. 1988. PMID: 2971536 Free PMC article. - Oncogenes take wing.
Bender W, Peifer M. Bender W, et al. Cell. 1987 Aug 14;50(4):519-20. doi: 10.1016/0092-8674(87)90023-7. Cell. 1987. PMID: 3111718 No abstract available. - Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling.
Siegfried E, Perrimon N. Siegfried E, et al. Bioessays. 1994 Jun;16(6):395-404. doi: 10.1002/bies.950160607. Bioessays. 1994. PMID: 8080429 Review. - The int genes in mouse mammary tumorigenesis and in normal development.
Nusse R. Nusse R. Ciba Found Symp. 1990;150:212-22; discussion 222-6. doi: 10.1002/9780470513927.ch13. Ciba Found Symp. 1990. PMID: 2164908 Review.
Cited by
- Canonical and Non-Canonical Wnt Signaling Generates Molecular and Cellular Asymmetries to Establish Embryonic Axes.
Shi DL. Shi DL. J Dev Biol. 2024 Aug 2;12(3):20. doi: 10.3390/jdb12030020. J Dev Biol. 2024. PMID: 39189260 Free PMC article. Review. - A large-scale in vivo screen to investigate the roles of human genes in Drosophila melanogaster.
Avila A, Paculis L, Tascon RG, Ramos B, Jia D. Avila A, et al. G3 (Bethesda). 2024 Oct 7;14(10):jkae188. doi: 10.1093/g3journal/jkae188. G3 (Bethesda). 2024. PMID: 39119785 Free PMC article. - Cell-cell communication: new insights and clinical implications.
Su J, Song Y, Zhu Z, Huang X, Fan J, Qiao J, Mao F. Su J, et al. Signal Transduct Target Ther. 2024 Aug 7;9(1):196. doi: 10.1038/s41392-024-01888-z. Signal Transduct Target Ther. 2024. PMID: 39107318 Free PMC article. Review. - Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease.
Hu L, Chen W, Qian A, Li YP. Hu L, et al. Bone Res. 2024 Jul 10;12(1):39. doi: 10.1038/s41413-024-00342-8. Bone Res. 2024. PMID: 38987555 Free PMC article. Review. - New insights in ubiquitin-dependent Wnt receptor regulation in tumorigenesis.
Tsukiyama T. Tsukiyama T. In Vitro Cell Dev Biol Anim. 2024 May;60(5):449-465. doi: 10.1007/s11626-024-00855-w. Epub 2024 Feb 21. In Vitro Cell Dev Biol Anim. 2024. PMID: 38383910 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases