Evolving spectrum of diabetic nephropathy - PubMed (original) (raw)

Review

Evolving spectrum of diabetic nephropathy

Jonathan Kopel et al. World J Diabetes. 2019.

Abstract

Diabetes remains an important health issue as more patients with chronic and uncontrolled diabetes develop diabetic nephropathy (DN), which classically presents with proteinuria followed by a progressive decrease in renal function. However, an increasing proportion of DN patients have a decline in kidney function and vascular complications without proteinuria, known as non-proteinuric DN (NP-DN). Despite the increased incidence of NP-DN, few clinical or experimental studies have thoroughly investigated the pathophysiological mechanisms and targeted treatment for this form of DN. In this review, we will examine the differences between conventional DN and NP-DN and consider potential pathophysiological mechanisms, diagnostic markers, and treatment for both DN and NP-DN. The investigation of the pathophysiology of NP-DN should provide additional insight into the cardiovascular factors influencing renal function and disease and provide novel treatments for the vascular complications seen in diabetic patients.

Keywords: Diabetes; Diabetic nephropathy; Kidney vascular complications; Non-proteinuric diabetic nephropathy.

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Conflict of interest statement

Conflict-of-interest statement: The authors whose names are listed immediately below certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

Figures

Figure 1

Figure 1

Pathophysiology of diabetic nephropathy and non-proteinuric diabetic nephropathy.

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