In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon - PubMed (original) (raw)
In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon
C O Jacob et al. J Exp Med. 1987.
Abstract
The (NZB X NZW)F1 mouse is recognized as an important animal model of the human disease systemic lupus erythematosus (SLE). Groups of NZB/W F1 mice were treated either with IFN-gamma or with PBS. The results demonstrate that IFN-treated animals have accelerated development of fatal immune complex glomerulonephritis relative to age-matched controls. On the other hand, administration of mAbs specific for IFN-gamma to such mice from 4 to 7 mo of age resulted in significant remission. Development of both proteinuria and anti-DNA antibodies were delayed and survival at 11 mo was increased from less than 20% to 95% in treated mice relative to controls (p less than or equal to 0.001). These findings may have therapeutic implications for the treatment of SLE.
Similar articles
- Animal models utilized in the research of autoimmune disease control: experimental therapy of glomerulonephritis in NZB/W F1 mice.
Okudaira H, Terada E, Okudaira K. Okudaira H, et al. Prog Clin Biol Res. 1987;229:157-74. Prog Clin Biol Res. 1987. PMID: 3601985 - CXCR3 promotes the production of IgG1 autoantibodies but is not essential for the development of lupus nephritis in NZB/NZW mice.
Moser K, Kalies K, Szyska M, Humrich JY, Amann K, Manz RA. Moser K, et al. Arthritis Rheum. 2012 Apr;64(4):1237-46. doi: 10.1002/art.33424. Epub 2011 Oct 17. Arthritis Rheum. 2012. PMID: 22006377 - Treatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc gamma receptor II (CD32).
Werwitzke S, Trick D, Sondermann P, Kamino K, Schlegelberger B, Kniesch K, Tiede A, Jacob U, Schmidt RE, Witte T. Werwitzke S, et al. Ann Rheum Dis. 2008 Feb;67(2):154-61. doi: 10.1136/ard.2006.068981. Epub 2007 Jun 8. Ann Rheum Dis. 2008. PMID: 17557887 - Origins of pathogenic anti-DNA idiotypes in the NZB X SWR model of lupus nephritis.
Datta SK, Gavalchin J. Datta SK, et al. Ann N Y Acad Sci. 1986;475:47-58. doi: 10.1111/j.1749-6632.1986.tb20855.x. Ann N Y Acad Sci. 1986. PMID: 2947530 Review. - Nuclease deficiencies promote end-stage lupus nephritis but not nephritogenic autoimmunity in (NZB × NZW) F1 mice.
Fismen S, Mortensen ES, Rekvig OP. Fismen S, et al. Immunol Cell Biol. 2011 Jan;89(1):90-9. doi: 10.1038/icb.2010.75. Epub 2010 Jun 15. Immunol Cell Biol. 2011. PMID: 20548325 Review.
Cited by
- Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis.
Akiyama Y, Harada K, Miyakawa J, Kreder KJ, O'Donnell MA, Daichi M, Katoh H, Hori M, Owari K, Futami K, Ishikawa S, Ushiku T, Kume H, Homma Y, Luo Y. Akiyama Y, et al. iScience. 2023 Oct 21;26(11):108262. doi: 10.1016/j.isci.2023.108262. eCollection 2023 Nov 17. iScience. 2023. PMID: 38026177 Free PMC article. - IFN-γ and TGF-β, Crucial Players in Immune Responses: A Tribute to Howard Young.
Gauthier T, Chen W. Gauthier T, et al. J Interferon Cytokine Res. 2022 Dec;42(12):643-654. doi: 10.1089/jir.2022.0132. J Interferon Cytokine Res. 2022. PMID: 36516375 Free PMC article. Review. - IFN-γ, should not be ignored in SLE.
Liu W, Zhang S, Wang J. Liu W, et al. Front Immunol. 2022 Aug 10;13:954706. doi: 10.3389/fimmu.2022.954706. eCollection 2022. Front Immunol. 2022. PMID: 36032079 Free PMC article. Review. - Immunomodulatory Activity of Mesenchymal Stem Cells in Lupus Nephritis: Advances and Applications.
Li J, Luo M, Li B, Lou Y, Zhu Y, Bai X, Sun B, Lu X, Luo P. Li J, et al. Front Immunol. 2022 Mar 10;13:843192. doi: 10.3389/fimmu.2022.843192. eCollection 2022. Front Immunol. 2022. PMID: 35359961 Free PMC article. Review.
References
- J Exp Med. 1978 Jun 1;147(6):1653-60 - PubMed
- N Engl J Med. 1978 Sep 7;299(10):515-8 - PubMed
- Infect Immun. 1978 Sep;21(3):925-30 - PubMed
- J Immunol. 1978 Dec;121(6):2213-9 - PubMed
- Biomedicine. 1979 Apr;31(2):48-51 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical