Hypereosinophilic Syndrome, Cardiomyopathies, and Sudden Cardiac Death in Superinvasive Opisthorchiasis - PubMed (original) (raw)
Hypereosinophilic Syndrome, Cardiomyopathies, and Sudden Cardiac Death in Superinvasive Opisthorchiasis
Vitaly G Bychkov et al. Cardiol Res Pract. 2019.
Abstract
Cardiovascular pathology in patients with superinvasive opisthorchiasis is characterized by severe changes in haemodynamics and myocardial metabolism, impaired automatism, excitability, and conduction of the heart muscle. An analysis of 578 cases (medical and outpatient records and reports of pathoanatomical and forensic autopsies) recorded in healthcare facilities treating opisthorchiasis patients with a hyperendemic focus was carried out. We identified a set of cardiac changes in patients with hypereosinophilic syndrome associated with superinvasive opisthorchiasis infection, classified the pathological processes in accordance with ICD-10, and described their pathogenesis.
Figures
Figure 1
Superinvasive opisthorchiasis (SO). Opisthorchis felineus in the different stages of the ontogenesis by haematoxylin and eosin (HE) staining (magnification 400x).
Figure 2
Oral sucker of Opisthorchis felineus by scanning electron microscopy.
Figure 3
Eosinophilic myocarditis. Parasite's exometabolite dispersal is shown by black arrows and altered cardiomyocytes are shown by red arrows (haematoxylin and eosin (HE) staining, magnification 400x).
Figure 4
SCD, HES, and diffuse eosinophilic myocarditis were visualized with haematoxylin and eosin (HE) staining (magnification 100x).
Figure 5
HES, diffuse eosinophilic myocarditis, intermuscular localization of granulocytes, dystrophy, and death of cardiomyocytes were visualized with haematoxylin and eosin (HE) staining (magnification 200x).
Figure 6
HES complicated by eosinophilic myocarditis, an aggression of granulocytes, and myolysis of cardiomyocytes were visualized with haematoxylin and eosin (HE) staining (magnification 200x).
Figure 7
SCD, HES, and metabolic necrosis complicated by eosinophilic myocarditis were visualized with haematoxylin and eosin (HE) staining (magnification 200x).
Figure 8
HES and eosinophilic infiltrates in the kidneys were visualized with haematoxylin and eosin (HE) staining (magnification 200x).
Figure 9
SCD, HES, and diffuse eosinophilic infiltrates in the gums were visualized with haematoxylin and eosin (HE) staining (magnification 200x).
Figure 10
HES and hyperplasia of lymphoid cells in the appendix were visualized with haematoxylin and eosin (HE) staining (magnification 200x).
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