The effect of ginger (Zingiber officinale) on chemotherapy-induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials - PubMed (original) (raw)
. 2019 Aug;33(8):1957-1965.
doi: 10.1002/ptr.6377. Epub 2019 Jun 21.
Affiliations
- PMID: 31225678
- DOI: 10.1002/ptr.6377
The effect of ginger (Zingiber officinale) on chemotherapy-induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials
Ali Saneei Totmaj et al. Phytother Res. 2019 Aug.
Abstract
Breast cancer is the most commonly diagnosed cancer and is the leading cause of mortality due to all types of cancers among the female population worldwide. Results of clinical trials investigating the effect of ginger on chemotherapy-induced nausea and vomiting (CINV) in breast cancer patients are inconsistent. This study was aimed at obtaining a comprehensive overview of the current evidence regarding the effectiveness of ginger as an antiemetic modality for controlling CINV in breast cancer patients. All published randomized controlled trials in English were systematically searched on Google Scholar, PubMed, Scopus, and Cochrane search databases up to June 2018. The outcome variable of interest was severity and the frequency of nausea and vomiting in patients. A total of 50 studies were found through search databases. After excluding duplicates, the 42 remaining studies were screened, and finally, nine trials were included, which were published between 2012 and 2017. Two studies have examined the effect of ginger on the frequency of nausea, five studies on the frequency of vomiting, seven studies on the severity of nausea, and three studies on severity of vomiting. A study evaluated the effectiveness of ginger in improving dietary intake in CINV. Our investigation suggests that ginger may reduce nausea in the acute phase of chemotherapy in patients with breast cancer. The effect of ginger on nausea and vomiting in other conditions requires more high-quality clinical trials.
Keywords: CINV; Zingiber officinale; breast cancer; chemotherapy; ginger; herbal therapy; nausea; vomiting.
© 2019 John Wiley & Sons, Ltd.
Similar articles
- Does the Oral Administration of Ginger Reduce Chemotherapy-Induced Nausea and Vomiting?: A Meta-analysis of 10 Randomized Controlled Trials.
Chang WP, Peng YX. Chang WP, et al. Cancer Nurs. 2019 Nov/Dec;42(6):E14-E23. doi: 10.1097/NCC.0000000000000648. Cancer Nurs. 2019. PMID: 30299420 - Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: a pilot, randomized, open-label clinical trial.
Panahi Y, Saadat A, Sahebkar A, Hashemian F, Taghikhani M, Abolhasani E. Panahi Y, et al. Integr Cancer Ther. 2012 Sep;11(3):204-11. doi: 10.1177/1534735411433201. Epub 2012 Feb 7. Integr Cancer Ther. 2012. PMID: 22313739 Clinical Trial. - Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review.
Marx WM, Teleni L, McCarthy AL, Vitetta L, McKavanagh D, Thomson D, Isenring E. Marx WM, et al. Nutr Rev. 2013 Apr;71(4):245-54. doi: 10.1111/nure.12016. Epub 2013 Mar 13. Nutr Rev. 2013. PMID: 23550785 Review. - Ginger as an antiemetic modality for chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis.
Lee J, Oh H. Lee J, et al. Oncol Nurs Forum. 2013 Mar;40(2):163-70. doi: 10.1188/13.ONF.163-170. Oncol Nurs Forum. 2013. PMID: 23448741 Review. - Efficacy and Safety of Ginger on the Side Effects of Chemotherapy in Breast Cancer Patients: Systematic Review and Meta-Analysis.
Kim SD, Kwag EB, Yang MX, Yoo HS. Kim SD, et al. Int J Mol Sci. 2022 Sep 24;23(19):11267. doi: 10.3390/ijms231911267. Int J Mol Sci. 2022. PMID: 36232567 Free PMC article. Review.
Cited by
- The Effect of Omega-3 Enriched Oral Nutrition Supplement on Nutritional Indices and Quality of Life in Gastrointestinal Cancer Patients: A Randomized Clinical Trial.
Sim E, Kim JM, Lee SM, Chung MJ, Song SY, Kim ES, Chun HJ, Sung MK. Sim E, et al. Asian Pac J Cancer Prev. 2022 Feb 1;23(2):485-494. doi: 10.31557/APJCP.2022.23.2.485. Asian Pac J Cancer Prev. 2022. PMID: 35225460 Free PMC article. Clinical Trial. - The Effect of Ginger and Its Sub-Components on Pain.
Kim S, Cheon C, Kim B, Kim W. Kim S, et al. Plants (Basel). 2022 Sep 2;11(17):2296. doi: 10.3390/plants11172296. Plants (Basel). 2022. PMID: 36079679 Free PMC article. Review. - 2023 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting.
Herrstedt J, Clark-Snow R, Ruhlmann CH, Molassiotis A, Olver I, Rapoport BL, Aapro M, Dennis K, Hesketh PJ, Navari RM, Schwartzberg L, Affronti ML, Garcia-Del-Barrio MA, Chan A, Celio L, Chow R, Fleury M, Gralla RJ, Giusti R, Jahn F, Iihara H, Maranzano E, Radhakrishnan V, Saito M, Sayegh P, Bosnjak S, Zhang L, Lee J, Ostwal V, Smit T, Zilic A, Jordan K, Scotté F; participants of the MASCC/ESMO Consensus Conference 2022. Electronic address: clinicalguidelines@esmo.org. Herrstedt J, et al. ESMO Open. 2024 Feb;9(2):102195. doi: 10.1016/j.esmoop.2023.102195. Epub 2024 Jan 11. ESMO Open. 2024. PMID: 38458657 Free PMC article. - Influence of Diet on the Bioavailability of Active Components from Zingiber officinale Using an In Vitro Digestion Model.
Zagórska J, Pietrzak K, Kukula-Koch W, Czop M, Laszuk J, Koch W. Zagórska J, et al. Foods. 2023 Oct 24;12(21):3897. doi: 10.3390/foods12213897. Foods. 2023. PMID: 37959015 Free PMC article. - Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials.
Anh NH, Kim SJ, Long NP, Min JE, Yoon YC, Lee EG, Kim M, Kim TJ, Yang YY, Son EY, Yoon SJ, Diem NC, Kim HM, Kwon SW. Anh NH, et al. Nutrients. 2020 Jan 6;12(1):157. doi: 10.3390/nu12010157. Nutrients. 2020. PMID: 31935866 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical