T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens - PubMed (original) (raw)

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. 1988 Mar 3;332(6159):40-5.

doi: 10.1038/332040a0.

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• PMID: 3126397
• DOI: 10.1038/332040a0

Review

T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens

H R MacDonald et al. Nature. 1988.

Abstract

T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor beta-chain variable gene segment (V beta 6). Such V beta 6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion.

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