Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae - PubMed (original) (raw)

Comparative Study

. 1988 Mar 10;332(6160):173-6.

doi: 10.1038/332173a0.

Affiliations

• PMID: 3126399
• DOI: 10.1038/332173a0

Comparative Study

Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae

B G Spratt. Nature. 1988.

Abstract

Benzylpenicillin has been used extensively for approximately 40 years in the treatment of gonorrhoea. The intense selective pressures resulting from the continual exposure of Neisseria gonorrhoeae to penicillin have resulted in the emergence of resistant strains that produce altered forms of penicillin-binding proteins (PBPs) with decreased affinity for the antibiotic. A comparison of the sequences of the PBP-2 genes from penicillin-sensitive and penicillin-resistant strains, suggests that penicillin-resistant forms of PBP 2 may have arisen both by amino-acid substitutions and insertions, and by the exchange of a region encoding part of the penicillin-sensitive transpeptidase domain with the homologous region from a closely related species.

PubMed Disclaimer

Similar articles

• Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis.
  Spratt BG, Zhang QY, Jones DM, Hutchison A, Brannigan JA, Dowson CG. Spratt BG, et al. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8988-92. doi: 10.1073/pnas.86.22.8988. Proc Natl Acad Sci U S A. 1989. PMID: 2510173 Free PMC article.
• Penicillin-binding protein 2 genes of non-beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae.
  Dowson CG, Jephcott AE, Gough KR, Spratt BG. Dowson CG, et al. Mol Microbiol. 1989 Jan;3(1):35-41. doi: 10.1111/j.1365-2958.1989.tb00101.x. Mol Microbiol. 1989. PMID: 2497297
• Nucleotide sequence of the penicillin-binding protein 2 gene of Neisseria meningitidis.
  Zhang QY, Spratt BG. Zhang QY, et al. Nucleic Acids Res. 1989 Jul 11;17(13):5383. doi: 10.1093/nar/17.13.5383. Nucleic Acids Res. 1989. PMID: 2503813 Free PMC article. No abstract available.
• Epidemiology and molecular basis of penicillin-resistant Neisseria meningitidis in Spain: a 5-year history (1985-1989).
  Sáez-Nieto JA, Lujan R, Berrón S, Campos J, Viñas M, Fusté C, Vazquez JA, Zhang QY, Bowler LD, Martinez-Suarez JV, et al. Sáez-Nieto JA, et al. Clin Infect Dis. 1992 Feb;14(2):394-402. doi: 10.1093/clinids/14.2.394. Clin Infect Dis. 1992. PMID: 1554823 Review.
• Penicillin-binding protein-mediated resistance in pneumococci and staphylococci.
  Chambers HF. Chambers HF. J Infect Dis. 1999 Mar;179 Suppl 2:S353-9. doi: 10.1086/513854. J Infect Dis. 1999. PMID: 10081507 Review.

Cited by

• Quantifying homologous replacement of loci between haloarchaeal species.
  Williams D, Gogarten JP, Papke RT. Williams D, et al. Genome Biol Evol. 2012;4(12):1223-44. doi: 10.1093/gbe/evs098. Genome Biol Evol. 2012. PMID: 23160063 Free PMC article.
• Relatedness of penicillin-binding protein 1a genes from different clones of penicillin-resistant Streptococcus pneumoniae isolated in South Africa and Spain.
  Martin C, Sibold C, Hakenbeck R. Martin C, et al. EMBO J. 1992 Nov;11(11):3831-6. doi: 10.1002/j.1460-2075.1992.tb05475.x. EMBO J. 1992. PMID: 1396576 Free PMC article.
• Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae.
  Laible G, Hakenbeck R. Laible G, et al. J Bacteriol. 1991 Nov;173(21):6986-90. doi: 10.1128/jb.173.21.6986-6990.1991. J Bacteriol. 1991. PMID: 1938899 Free PMC article.
• Identification and analysis of amino acid mutations in porin IB that mediate intermediate-level resistance to penicillin and tetracycline in Neisseria gonorrhoeae.
  Olesky M, Hobbs M, Nicholas RA. Olesky M, et al. Antimicrob Agents Chemother. 2002 Sep;46(9):2811-20. doi: 10.1128/AAC.46.9.2811-2820.2002. Antimicrob Agents Chemother. 2002. PMID: 12183233 Free PMC article.
• The Impact of Nucleotide Sequence Analysis on Meningococcal Vaccine Development and Assessment.
  Maiden MCJ. Maiden MCJ. Front Immunol. 2019 Jan 15;9:3151. doi: 10.3389/fimmu.2018.03151. eCollection 2018. Front Immunol. 2019. PMID: 30697213 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal