Hyperhomocysteinemia Associated with Low Muscle Mass, Muscle Function in Elderly Hemodialysis Patients: An Analysis of Multiple Dialysis Centers - PubMed (original) (raw)

. 2019 Jun 9:2019:9276097.

doi: 10.1155/2019/9276097. eCollection 2019.

Te-Chih Wong 2, Tuyen Van Duong 1, Chien-Tien Su 3 4, Hsi-Hsien Chen 5 6, Tso-Hsiao Chen 5 7, Yung-Ho Hsu 5 8, Sheng-Jeng Peng 9, Ko-Lin Kuo 10, Hsiang-Chung Liu 11, En-Tzu Lin 12, Yi-Wei Feng 1, Shwu-Huey Yang 1 13 14

Affiliations

Hyperhomocysteinemia Associated with Low Muscle Mass, Muscle Function in Elderly Hemodialysis Patients: An Analysis of Multiple Dialysis Centers

Chi-Sin Wang et al. Biomed Res Int. 2019.

Abstract

Background: The hyperhomocysteinemia was with high prevalence and has been considered as a risk factor for cardiovascular disease in hemodialysis patients. These patients also experienced a high risk of muscle wasting caused by the comorbidity, malnutrition, and low physical activity. We investigated the associations of homocysteinemia with muscle mass, muscle function in elderly hemodialysis patients.

Methods: A clinical cross-sectional study was conducted on 138 hemodialysis patients aged 65 years and above in seven hospital-based hemodialysis centers in Taiwan. The data on anthropometry, laboratory, and 3-day dietary intake was examined. The skeletal muscle mass (SMM) was measured by the bioelectrical impedance analysis; the SMM was adjusted by height or weight as SMMHt2 (kg/m2) and SMMWt (%). Muscle function was defined as handgrip strength (HGS) (kg) measured by handgrip dynamometer. Statistical analyses were conducted using simple regression and multivariable stepwise regression analysis.

Results: In the total sample, 74.6 % of hemodialysis patients were hyperhomocysteinemia (≥ 15 _μ_mol/L). The means of SMMHt2, SMMWt, arm lean mass, hand grip strength, and muscle quality were 8.7 ± 1.2, 37.7 ± 5.6, 1.7 ± 0.5, 21.1 ± 7.4, and 10.0 ± 3.0, respectively. The multivariable stepwise regression analysis showed that homocysteinemia level was significantly inversely associated with SMMWt (B-coeff. = -0.03, p = 0.02) in hemodialysis patients above 65 years old, but not with muscle function.

Conclusions: Hyperhomocysteinemia is common and associated with decreased muscle mass in the elderly hemodialysis patients. Future studies are suggested to explore the impact of the homocysteine-lowering therapy on muscle decline.

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