Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element - PubMed (original) (raw)
Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element
F LaBella et al. Genes Dev. 1988 Jan.
Free article
Abstract
Mammalian histone gene transcription is increased approximately fivefold during the transition from the G1 phase to the S phase of the cell cycle. In this study, we present a detailed in vivo analysis of the human histone H2b promoter, which establishes that transcriptional regulation of this gene is mediated by a subtype-specific consensus element containing the core octanucleotide ATTTGCAT. Our results demonstrate that the activity of this sequence is specific for S phase. Comparative analysis of different replication variant mammalian histone gene promoters and our knowledge of the transcription factors interacting with the human histone H2b and H4 promoters allow us to conclude that coordinate regulation of histone gene transcription in higher eukaryotes is mediated by distinct factors. We propose a simple model for transcriptional regulation of mammalian histone gene expression, which incorporates both the distinct features of the individual histone gene promoters and the apparent functional equivalence of the specific sequence elements regulating transcription of each histone gene subtype.
Similar articles
- Histone H1 subtype-specific consensus elements mediate cell cycle-regulated transcription in vitro.
La Bella F, Gallinari P, McKinney J, Heintz N. La Bella F, et al. Genes Dev. 1989 Dec;3(12A):1982-90. doi: 10.1101/gad.3.12a.1982. Genes Dev. 1989. PMID: 2620829 - A variant octamer motif in a Xenopus H2B histone gene promoter is not required for transcription in frog oocytes.
Hinkley C, Perry M. Hinkley C, et al. Mol Cell Biol. 1991 Feb;11(2):641-54. doi: 10.1128/mcb.11.2.641-654.1991. Mol Cell Biol. 1991. PMID: 1990276 Free PMC article. - Multiple sequence elements are required for maximal in vitro transcription of a human histone H2B gene.
Sive HL, Heintz N, Roeder RG. Sive HL, et al. Mol Cell Biol. 1986 Oct;6(10):3329-40. doi: 10.1128/mcb.6.10.3329-3340.1986. Mol Cell Biol. 1986. PMID: 3025588 Free PMC article. - Modifications in molecular mechanisms associated with control of cell cycle regulated human histone gene expression during differentiation.
Stein GS, Stein JL, Lian JB, Van Wijnen AJ, Wright KL, Pauli U. Stein GS, et al. Cell Biophys. 1989 Dec;15(3):201-23. doi: 10.1007/BF02989684. Cell Biophys. 1989. PMID: 2480181 Review.
Cited by
- Coordinated expression of replication-dependent histone genes from multiple loci promotes histone homeostasis in Drosophila.
Chaubal A, Waldern JM, Taylor C, Laederach A, Marzluff WF, Duronio RJ. Chaubal A, et al. Mol Biol Cell. 2023 Nov 1;34(12):ar118. doi: 10.1091/mbc.E22-11-0532. Epub 2023 Aug 30. Mol Biol Cell. 2023. PMID: 37647143 Free PMC article. - Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming.
Malik V, Zimmer D, Jauch R. Malik V, et al. Cell Mol Life Sci. 2018 May;75(9):1587-1612. doi: 10.1007/s00018-018-2748-5. Epub 2018 Jan 15. Cell Mol Life Sci. 2018. PMID: 29335749 Free PMC article. Review. - Octamer-binding transcription factors: genomics and functions.
Zhao FQ. Zhao FQ. Front Biosci (Landmark Ed). 2013 Jun 1;18(3):1051-71. doi: 10.2741/4162. Front Biosci (Landmark Ed). 2013. PMID: 23747866 Free PMC article. Review. - Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes.
He H, Lee MC, Zheng LL, Zheng L, Luo Y. He H, et al. Biosci Rep. 2013 Feb 1;33(2):e00018. doi: 10.1042/BSR20120059. Biosci Rep. 2013. PMID: 23134369 Free PMC article. - CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes.
He H, Yu FX, Sun C, Luo Y. He H, et al. PLoS One. 2011;6(7):e22088. doi: 10.1371/journal.pone.0022088. Epub 2011 Jul 15. PLoS One. 2011. PMID: 21789216 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources