Amplification of the hst-1 gene in human esophageal carcinomas - PubMed (original) (raw)

Amplification of the hst-1 gene in human esophageal carcinomas

T Tsuda et al. Jpn J Cancer Res. 1988 May.

Abstract

The hst-1 gene, previously designated as the hst gene, and seven other oncogenes were examined for possible structural changes in esophageal, gastric and colorectal carcinomas by Southern blot hybridization. The hst-1 gene was amplified in eight (42.1%) of the nineteen esophageal squamous cell carcinomas and in all four metastatic tumors of lymph nodes. The degree of amplification ranged from two to eight times. Coamplification of the hst-1 and c-erbB-1 gene was found in one case of esophageal carcinoma. However, no amplification of the hst-1 gene was detected in gastric and colorectal carcinomas.

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