bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia - PubMed (original) (raw)
Affiliations
- PMID: 3147434
bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia
I K Hariharan et al. Oncogene Res. 1988.
Abstract
In chronic myeloid leukemia (CML), a chromosome translocation has fused the bcr gene to the c-abl oncogene, such that a chimeric bcr-abl polypeptide can be made. To explore the biological properties of bcr-abl and compare them with those of the Abelson virus (AMuLV) transforming gene (gag-v-abl), we have used either a synthetic bcr-v-abl gene that mimics the translocation product or, in some experiments, a bcr-c-abl cDNA. A new retroviral vector was used to introduce the genes into the factor-dependent myeloid line FDC-P1. Both bcr-abl and v-abl efficiently rendered the myeloid cells factor independent and tumorigenic. Their fully autonomous growth may be due to the myeloid growth factor interleukin-3 (IL-3) made in small amounts by the infected cells. Hence autocrine factor production may feature in CML development and Abelson virus transformation.
Similar articles
- Bcr-Abl has a greater intrinsic capacity than v-Abl to induce the neoplastic expansion of myeloid cells.
Gross AW, Ren R. Gross AW, et al. Oncogene. 2000 Dec 14;19(54):6286-96. doi: 10.1038/sj.onc.1204023. Oncogene. 2000. PMID: 11175343 - Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line.
Matulonis U, Salgia R, Okuda K, Druker B, Griffin JD. Matulonis U, et al. Exp Hematol. 1993 Oct;21(11):1460-6. Exp Hematol. 1993. PMID: 8405226 - Autocrine and paracrine effects of an ES-cell derived, BCR/ABL-transformed hematopoietic cell line that induces leukemia in mice.
Peters DG, Klucher KM, Perlingeiro RC, Dessain SK, Koh EY, Daley GQ. Peters DG, et al. Oncogene. 2001 May 10;20(21):2636-46. doi: 10.1038/sj.onc.1204374. Oncogene. 2001. PMID: 11420675 - Molecular mechanisms of transformation by the BCR-ABL oncogene.
Sattler M, Griffin JD. Sattler M, et al. Semin Hematol. 2003 Apr;40(2 Suppl 2):4-10. doi: 10.1053/shem.2003.50034. Semin Hematol. 2003. PMID: 12783368 Review. - The role of myc in transformation by BCR-ABL.
Sawyers CL. Sawyers CL. Leuk Lymphoma. 1993;11 Suppl 1:45-6. doi: 10.3109/10428199309047862. Leuk Lymphoma. 1993. PMID: 8251915 Review.
Cited by
- Impaired DNA replication within progenitor cell pools promotes leukemogenesis.
Bilousova G, Marusyk A, Porter CC, Cardiff RD, DeGregori J. Bilousova G, et al. PLoS Biol. 2005 Dec;3(12):e401. doi: 10.1371/journal.pbio.0030401. Epub 2005 Nov 15. PLoS Biol. 2005. PMID: 16277552 Free PMC article. - Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.
Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DC, Kimura S, Ottmann OG, Druker BJ, Villunger A, Roberts AW, Strasser A. Kuroda J, et al. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14907-12. doi: 10.1073/pnas.0606176103. Epub 2006 Sep 22. Proc Natl Acad Sci U S A. 2006. PMID: 16997913 Free PMC article. - Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.
LaMontagne KR Jr, Flint AJ, Franza BR Jr, Pandergast AM, Tonks NK. LaMontagne KR Jr, et al. Mol Cell Biol. 1998 May;18(5):2965-75. doi: 10.1128/MCB.18.5.2965. Mol Cell Biol. 1998. PMID: 9566916 Free PMC article. - Expression of two different forms of fibroblast growth factor receptor 1 in different mouse tissues and cell lines.
Bernard O, Li M, Reid HH. Bernard O, et al. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7625-9. doi: 10.1073/pnas.88.17.7625. Proc Natl Acad Sci U S A. 1991. PMID: 1715572 Free PMC article. - IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease.
Wong S, McLaughlin J, Cheng D, Shannon K, Robb L, Witte ON. Wong S, et al. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11630-5. doi: 10.1073/pnas.2035020100. Epub 2003 Sep 19. Proc Natl Acad Sci U S A. 2003. PMID: 14500898 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Miscellaneous