Effect Of Three Pakistani Date-Seed Varieties On Lipid Profile Of Diet Induced Hyperlipidemic Rabbits - PubMed (original) (raw)
. 2019 Jul-Sep;31(3):326-330.
Affiliations
- PMID: 31535499
Free article
Effect Of Three Pakistani Date-Seed Varieties On Lipid Profile Of Diet Induced Hyperlipidemic Rabbits
Mahwash Malik et al. J Ayub Med Coll Abbottabad. 2019 Jul-Sep.
Free article
Abstract
Background: Hyperlipidemia is one of the major risk factors of cardiovascular diseases. In addition to current therapeutic strategies, a lot of work is being done on nutraceutical management of this condition. This study was designed to assess the effect of date seed powder on lipid profile of diet induced hyperlipidemic rabbits.
Methods: Thirty male rabbits were divided into five groups, having six animals in each. One group was given normal rabbit chow throughout the study period of eight weeks. The remaining four groups were fed high fat diet (4% coconut oil and 1% cholesterol powder) for first four weeks in order to induce hyperlipidemia. After first four weeks, 2% date seed powder of three Pakistani varieties namely Dhakki, Khudrawi and Desi was added to the diet of three experimental hyperlipidemic groups for the next four weeks. Body weight and blood samples were taken at zero, 4th and 8th week of study. Serum was analyzed for total cholesterol, LDL-cholesterol, HDL-cholesterol and serum triglycerides. LDL/HDL ratio and AIP were calculated.
Results: It was observed that date seed powder of the three varieties significantly decreased total cholesterol, serum triglycerides and AIP. There was no significant change in body weight, HDL-cholesterol, and LDL/HDL ratio. LDL cholesterol was decreased significantly only by Khudrawi date seed powder.
Conclusions: It was concluded that date seed powder has marked antihyperlipidemic properties. However, the difference in appearance, taste and price of different dates does not affect their lipid lowering capacity.
Keywords: Date-seed, P.Dactylifera; Hyperlipidemia; Lipid profile.
Similar articles
- Effect of Phoenix dactylifera seeds (dates) extract in triton WR-1339 and high fat diet induced hyperlipidaemia in rats: A comparison with simvastatin.
Bouhlali EDT, Hmidani A, Bourkhis B, Khouya T, Harnafi H, Filali-Zegzouti Y, Alem C. Bouhlali EDT, et al. J Ethnopharmacol. 2020 Sep 15;259:112961. doi: 10.1016/j.jep.2020.112961. Epub 2020 May 11. J Ethnopharmacol. 2020. PMID: 32423881 - Anti hyperlipidemic and hepatoprotective effects of native date fruit variety "Aseel" (Phoenix dactylifera).
Ahmed S, Khan RA, Jamil S. Ahmed S, et al. Pak J Pharm Sci. 2016 Nov;29(6):1945-1950. Pak J Pharm Sci. 2016. PMID: 28375109 - Hypolipidemic effect of fenugreek seeds and its comparison with atorvastatin on experimentally induced hyperlipidemia.
Sharma MS, Choudhary PR. Sharma MS, et al. J Coll Physicians Surg Pak. 2014 Aug;24(8):539-42. J Coll Physicians Surg Pak. 2014. PMID: 25149829 - In vivo evaluation of hypolipidemic and antioxidative effect of 'Ajwa' (Phoenix dactylifera L.) date seed-extract in high-fat diet-induced hyperlipidemic rat model.
Khan TJ, Kuerban A, Razvi SS, Mehanna MG, Khan KA, Almulaiky YQ, Faidallah HM. Khan TJ, et al. Biomed Pharmacother. 2018 Nov;107:675-680. doi: 10.1016/j.biopha.2018.07.134. Epub 2018 Aug 17. Biomed Pharmacother. 2018. PMID: 30125841 - Exercise and Hyperlipidemia.
He N, Ye H. He N, et al. Adv Exp Med Biol. 2020;1228:79-90. doi: 10.1007/978-981-15-1792-1_5. Adv Exp Med Biol. 2020. PMID: 32342451 Review.
Cited by
- Effect of dates on blood glucose and lipid profile among patients with type 2 diabetes.
Mirghani HO. Mirghani HO. World J Diabetes. 2024 Jun 15;15(6):1079-1085. doi: 10.4239/wjd.v15.i6.1079. World J Diabetes. 2024. PMID: 38983813 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous