Influenza viruses as lymphocyte mitogens. I. B cell mitogenesis by influenza A viruses of the H2 and H6 subtypes is controlled by the I-E/C subregion of the major histocompatibility complex - PubMed (original) (raw)
. 1985 Feb;134(2):757-60.
- PMID: 3155540
Influenza viruses as lymphocyte mitogens. I. B cell mitogenesis by influenza A viruses of the H2 and H6 subtypes is controlled by the I-E/C subregion of the major histocompatibility complex
A A Scalzo et al. J Immunol. 1985 Feb.
Abstract
Influenza A viruses of the H2, H3, and H6 subtypes function as T cell-independent B cell mitogens for lymphocytes from BALB/c mice. Lymphocytes from C57BL/10 mice, however, undergo mitogenesis only in response to H3 viruses. The failure of C57BL/10 lymphocytes to respond to H2 and H6 viruses was shown not to reflect a difference in dose-response profile or kinetics of the response, nor was it due to the activity of suppressor T cells. Experiments with congenic and recombinant strains of mice established that mitogenic responsiveness to H2 and H6 viruses is linked to the major histocompatibility complex, and is controlled by a gene located in the I-E/C subregion. Furthermore, responsiveness was shown to correlate with the expression of surface I-E antigen, being positive for mouse strains that express I-E antigen (haplotypes a, d, k, p, r) and negative for strains that do not (haplotypes b, f, q, s). The data suggest that influenza A viruses of the H2 and H6 subtypes may interact directly with I-E molecules on the surface of B cells or possibly on an accessory cell. Because mitogenesis by H3 viruses is not I-E dependent, it appears that influenza A viruses stimulate B cell mitogenesis by at least two different mechanisms.
Similar articles
- Mitogenic activity of influenza virus and haemagglutinin.
Anders EM, Scalzo AA, White DO. Anders EM, et al. Vaccine. 1985 Sep;3(3 Suppl):241-4. doi: 10.1016/0264-410x(85)90115-x. Vaccine. 1985. PMID: 3877381 - Regulation of the immune response T-cell interactions.
Dutton RW, Swain SL. Dutton RW, et al. CRC Crit Rev Immunol. 1982 Feb;3(3):209-61. CRC Crit Rev Immunol. 1982. PMID: 6176399 Review. No abstract available. - H2 gene control and biological activities of a T-cell mitogen derived from Mycoplasma arthritidis: a review.
Cole BC. Cole BC. Yale J Biol Med. 1983 Sep-Dec;56(5-6):605-12. Yale J Biol Med. 1983. PMID: 6433573 Free PMC article. Review.
Cited by
- Influenza, immune system, and pregnancy.
Raj RS, Bonney EA, Phillippe M. Raj RS, et al. Reprod Sci. 2014 Dec;21(12):1434-51. doi: 10.1177/1933719114537720. Epub 2014 Jun 4. Reprod Sci. 2014. PMID: 24899469 Free PMC article. Review. - In vivo polyclonal B-lymphocyte activation elicited by murine viruses.
Coutelier JP, Coulie PG, Wauters P, Heremans H, van der Logt JT. Coutelier JP, et al. J Virol. 1990 Nov;64(11):5383-8. doi: 10.1128/JVI.64.11.5383-5388.1990. J Virol. 1990. PMID: 1976818 Free PMC article. - Activated B cells can deliver help for the in vitro generation of antiviral cytotoxic T cells.
Liu Y, Müllbacher A. Liu Y, et al. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4629-33. doi: 10.1073/pnas.86.12.4629. Proc Natl Acad Sci U S A. 1989. PMID: 2786634 Free PMC article. - Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells.
Hargadon KM, Zhou H, Albrecht RA, Dodd HA, García-Sastre A, Braciale TJ. Hargadon KM, et al. J Virol. 2011 Nov;85(22):11955-63. doi: 10.1128/JVI.05830-11. Epub 2011 Sep 14. J Virol. 2011. PMID: 21917972 Free PMC article. - Influenza-like infection and laryngeal cancer.
Wiwanitkit V. Wiwanitkit V. Eur Arch Otorhinolaryngol. 2015 Aug;272(8):2085. doi: 10.1007/s00405-015-3567-z. Epub 2015 Feb 27. Eur Arch Otorhinolaryngol. 2015. PMID: 25721197 No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources