Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease - PubMed (original) (raw)
Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease
G A Graveland et al. Science. 1985.
Abstract
Golgi impregnations of neostriatum from deceased Huntington's disease patients and controls were examined. In all cases of Huntington's disease the morphology of dendrites of medium-sized spiny neurons was markedly altered by the appearance of recurved endings and appendages, a decrease or increase in the density of spines, and abnormalities in the size and shape of spines. Pathological changes were rarely observed in medium-sized and large aspiny neostriatal neurons. The findings provide evidence for simultaneous degeneration and growth of spiny neurons in Huntington's disease and support the view that a specific population of neostriatal neurons is selectively involved in its pathogenesis.
Similar articles
- Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry.
Ferrante RJ, Kowall NW, Richardson EP Jr. Ferrante RJ, et al. J Neurosci. 1991 Dec;11(12):3877-87. doi: 10.1523/JNEUROSCI.11-12-03877.1991. J Neurosci. 1991. PMID: 1836019 Free PMC article. - Striatal interneurons in Huntington's disease: selective increase in the density of calretinin-immunoreactive medium-sized neurons.
Cicchetti F, Parent A. Cicchetti F, et al. Mov Disord. 1996 Nov;11(6):619-26. doi: 10.1002/mds.870110605. Mov Disord. 1996. PMID: 8914086 - [Huntington disease: 7 cases with relatively preserved neostriatal islets].
Vonsattel JP, Myers RH, Bird ED, Ge P, Richardson EP Jr. Vonsattel JP, et al. Rev Neurol (Paris). 1992;148(2):107-16. Rev Neurol (Paris). 1992. PMID: 1534925 Review. French. - The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington's chorea.
Huot P, Lévesque M, Parent A. Huot P, et al. Brain. 2007 Jan;130(Pt 1):222-32. doi: 10.1093/brain/awl332. Epub 2006 Dec 2. Brain. 2007. PMID: 17142832 - Mitochondrial fragmentation in neuronal degeneration: Toward an understanding of HD striatal susceptibility.
Cherubini M, Ginés S. Cherubini M, et al. Biochem Biophys Res Commun. 2017 Feb 19;483(4):1063-1068. doi: 10.1016/j.bbrc.2016.08.042. Epub 2016 Aug 8. Biochem Biophys Res Commun. 2017. PMID: 27514446 Review.
Cited by
- Increased striatal dopamine in carriers of GBA mutations: compensation or epiphenomenon?
Bohnen NI, Albin RL. Bohnen NI, et al. Lancet Neurol. 2020 Jan;19(1):27-29. doi: 10.1016/S1474-4422(19)30355-2. Epub 2019 Oct 31. Lancet Neurol. 2020. PMID: 31678033 Free PMC article. No abstract available. - Striatal Neurodegeneration that Mimics Huntington's Disease Modifies GABA-induced Currents.
Flores-Hernández J, Garzón-Vázquez JA, Hernández-Carballo G, Nieto-Mendoza E, Ruíz-Luna EA, Hernández-Echeagaray E. Flores-Hernández J, et al. Brain Sci. 2018 Dec 6;8(12):217. doi: 10.3390/brainsci8120217. Brain Sci. 2018. PMID: 30563250 Free PMC article. - Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes.
Tousley A, Iuliano M, Weisman E, Sapp E, Richardson H, Vodicka P, Alexander J, Aronin N, DiFiglia M, Kegel-Gleason KB. Tousley A, et al. PLoS One. 2019 Feb 15;14(2):e0212337. doi: 10.1371/journal.pone.0212337. eCollection 2019. PLoS One. 2019. PMID: 30768638 Free PMC article. - Impact of ER Stress and ER-Mitochondrial Crosstalk in Huntington's Disease.
Maity S, Komal P, Kumar V, Saxena A, Tungekar A, Chandrasekar V. Maity S, et al. Int J Mol Sci. 2022 Jan 11;23(2):780. doi: 10.3390/ijms23020780. Int J Mol Sci. 2022. PMID: 35054963 Free PMC article. Review. - Cell-intrinsic drivers of dendrite morphogenesis.
Puram SV, Bonni A. Puram SV, et al. Development. 2013 Dec;140(23):4657-71. doi: 10.1242/dev.087676. Development. 2013. PMID: 24255095 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical