The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial - PubMed (original) (raw)
Randomized Controlled Trial
doi: 10.1016/j.ctim.2019.102201. Epub 2019 Sep 26.
Affiliations
- PMID: 31780025
- DOI: 10.1016/j.ctim.2019.102201
Randomized Controlled Trial
The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial
Sara Sohaei et al. Complement Ther Med. 2019 Dec.
Abstract
Objective: The aim of the current study was to assess the effects of curcumin supplementation on glycemic status, lipid profile and high sensitivity C-reactive protein (hs-CRP) serum levels in women with polycystic ovary syndrome (PCOS).
Design: This randomized double-blind placebo-controlled clinical trial was conducted on 60 women who were randomly assigned to the intervention or control groups using block randomization.
Setting: Infertility referral center.
Interventions: Curcumin (500 mg/d) or placebo twice daily for 6 weeks.
Main outcome measures: Serum evaluation of lipid profile (triglycerides (TG), low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol concentrations, LDL/HDL-C and TG/HDL-C ratios), glycemic index (fasting blood sugar (FBS), insulin concentrations, homeostasis model of assessment insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)) and hs-CRP levels.
Results: Glycemic index, lipid profile and hs-CRP serum levels were measured at first and at the end of trial. Serum insulin (p = 0.020) and Quantitative Insulin Sensitivity Check Index (QUICKI) (p = 0.003) were improved significantly, while Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (p = 0.067) improved marginally in curcumin treated group (within group analysis).
Conclusions: Curcumin supplementation might be beneficial for improving serum insulin and QUICKI, however, future investigations are suggested in order to draw a firm link between curcumin and glycemia control.
Keywords: Curcumin; Hyperlipidemia; Infertility; Insulin resistance; PCOS; hs-CRP.
Copyright © 2019. Published by Elsevier Ltd.
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