Effects of Spirulina supplementation on obesity: A systematic review and meta-analysis of randomized clinical trials - PubMed (original) (raw)
Meta-Analysis
Effects of Spirulina supplementation on obesity: A systematic review and meta-analysis of randomized clinical trials
Sajjad Moradi et al. Complement Ther Med. 2019 Dec.
Abstract
Objective: Evidence has suggested that Spirulina supplementation may affect anthropometric indices. Therefore, a systematic review and meta-analysis was performed to summarize published randomized clinical trials which assess the effect of Spirulina supplementation on obesity.
Setting: Pertinent studies were identified using Embase, Scopus, ISI Web of Science, PubMed and Cochrane library databases up to May 2019. Mean Differences (MD) were pooled using a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods.
Results: Results of 5 studies (7 treatment arms) showed a significant reduction in weight (MD: -1.56 Kg, 95% CI: -1.98 to -1.14) after Spirulina supplementation. Subgroup analysis based on health status revealed that weight change in obese subjects (MD: -2.06 Kg, 95% CI: -2.45 to -1.68) was greater than overweight participants (MD: -1.28 Kg, 95% CI: -1.62 to -0.93) following Spirulina supplementation. Also, pooled analysis showed that Spirulina supplementation led to a significant reduction in body fat percent (MD: -1.02, 95% CI: -1.49 to -0.54) and waist circumference (MD: -1.40, 95% CI: -1.40 to -1.39), but not in body mass index and waist to hip ratio.
Conclusion: Spirulina supplementation significantly reduces body weight, especially in obese individuals.
Keywords: Meta-analysis; Obesity; Spirulina; Systematic review.
Copyright © 2019. Published by Elsevier Ltd.
Similar articles
- Spirulina supplementation and anthropometric indices: A systematic review and meta-analysis of controlled clinical trials.
Zarezadeh M, Faghfouri AH, Radkhah N, Foroumandi E, Khorshidi M, Rasouli A, Zarei M, Mohammadzadeh Honarvar N, Hazhir Karzar N, Ebrahimi Mamaghani M. Zarezadeh M, et al. Phytother Res. 2021 Feb;35(2):577-586. doi: 10.1002/ptr.6834. Epub 2020 Sep 23. Phytother Res. 2021. PMID: 32967062 - Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials.
Askarpour M, Hadi A, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E. Askarpour M, et al. Pharmacol Res. 2020 Jan;151:104554. doi: 10.1016/j.phrs.2019.104554. Epub 2019 Nov 17. Pharmacol Res. 2020. PMID: 31743774 - Behavioral and Pharmacotherapy Weight Loss Interventions to Prevent Obesity-Related Morbidity and Mortality in Adults: An Updated Systematic Review for the U.S. Preventive Services Task Force [Internet].
LeBlanc EL, Patnode CD, Webber EM, Redmond N, Rushkin M, O’Connor EA. LeBlanc EL, et al. Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 Sep. Report No.: 18-05239-EF-1. Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 Sep. Report No.: 18-05239-EF-1. PMID: 30354042 Free Books & Documents. Review. - The effects of flaxseed (Linum usitatissimum) supplementation on anthropometric indices: An updated systematic review and meta-analysis of randomized clinical trials.
Musazadeh V, Abolghasemian M, Kavyani Z, Moridpour AH, Nazari A, Faghfouri AH. Musazadeh V, et al. Complement Ther Med. 2024 Sep;84:103066. doi: 10.1016/j.ctim.2024.103066. Epub 2024 Jul 9. Complement Ther Med. 2024. PMID: 38992480 Review.
Cited by
- The role of algae, fungi, and insect-derived proteins and bioactive peptides in preventive and clinical nutrition.
Yimam MA, Andreini M, Carnevale S, Muscaritoli M. Yimam MA, et al. Front Nutr. 2024 Oct 10;11:1461621. doi: 10.3389/fnut.2024.1461621. eCollection 2024. Front Nutr. 2024. PMID: 39449824 Free PMC article. Review. - Arthrospira platensis enriched with Cr(III), Mg(II), and Mn(II) ions improves insulin sensitivity and reduces systemic inflammation in equine metabolic affected horses.
Tomal A, Szłapka-Kosarzewska J, Mironiuk M, Michalak I, Marycz K. Tomal A, et al. Front Endocrinol (Lausanne). 2024 Apr 16;15:1382844. doi: 10.3389/fendo.2024.1382844. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38689728 Free PMC article. - Weight Loss Supplements.
Dini I, Mancusi A. Dini I, et al. Molecules. 2023 Jul 12;28(14):5357. doi: 10.3390/molecules28145357. Molecules. 2023. PMID: 37513229 Free PMC article. Review. - Nutraceutical Features of the Phycobiliprotein C-Phycocyanin: Evidence from Arthrospira platensis (Spirulina).
Citi V, Torre S, Flori L, Usai L, Aktay N, Dunford NT, Lutzu GA, Nieri P. Citi V, et al. Nutrients. 2024 Jun 3;16(11):1752. doi: 10.3390/nu16111752. Nutrients. 2024. PMID: 38892686 Free PMC article. Review. - Comprehensive Review of the Latest Investigations of the Health-Enhancing Effects of Selected Properties of Arthrospira and Spirulina Microalgae on Skin.
Chwil M, Mihelič R, Matraszek-Gawron R, Terlecka P, Skoczylas MM, Terlecki K. Chwil M, et al. Pharmaceuticals (Basel). 2024 Oct 3;17(10):1321. doi: 10.3390/ph17101321. Pharmaceuticals (Basel). 2024. PMID: 39458962 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical