Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma - PubMed (original) (raw)
Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma
T Hsu et al. Cell. 1988.
Abstract
Two hepatocellular carcinomas, induced in woodchucks chronically infected with woodchuck hepatitis virus, were characterized for viral integration near c-myc and alterations of c-myc expression. In one tumor, viral integration within the untranslated region of c-myc exon 3 resulted in overexpression of a long c-myc viral cotranscript. In the second tumor, a single insertion of highly rearranged viral sequences 600 bp upstream of c-myc exon 1 was associated with increased levels of normal c-myc mRNA. In both cases, viral enhancer insertion and disruption of normal c-myc transcriptional or posttranscriptional control appear to be involved in c-myc activation. These results demonstrate that integration of woodchuck hepatitis virus near a cellular proto-oncogene, as in several retroviral models, can contribute to the genesis of liver tumors.
Similar articles
- Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours.
Fourel G, Trepo C, Bougueleret L, Henglein B, Ponzetto A, Tiollais P, Buendia MA. Fourel G, et al. Nature. 1990 Sep 20;347(6290):294-8. doi: 10.1038/347294a0. Nature. 1990. PMID: 2205804 - [Hepatitis B virus and hepatocellular carcinoma].
Tiollais P, Dejean A, Buendia MA. Tiollais P, et al. Bull Acad Natl Med. 1991 Feb;175(2):263-71; discussion 271-2. Bull Acad Natl Med. 1991. PMID: 1650625 French. - [Hepatitis B virus and hepatocellular carcinoma].
Tiollais P, Dejean A, Buendia MA. Tiollais P, et al. Ann Gastroenterol Hepatol (Paris). 1991 Nov;27(6):288-92. Ann Gastroenterol Hepatol (Paris). 1991. PMID: 1772242 French. - Mammalian hepatitis B viruses and primary liver cancer.
Buendia MA. Buendia MA. Semin Cancer Biol. 1992 Oct;3(5):309-20. Semin Cancer Biol. 1992. PMID: 1335794 Review. - Woodchuck hepatitis virus infection: a model of human hepatic diseases and hepatocellular carcinoma.
Paronetto F, Tennant BC. Paronetto F, et al. Prog Liver Dis. 1990;9:463-83. Prog Liver Dis. 1990. PMID: 2156308 Review. No abstract available.
Cited by
- Frequent amplification of c-myc in ground squirrel liver tumors associated with past or ongoing infection with a hepadnavirus.
Transy C, Fourel G, Robinson WS, Tiollais P, Marion PL, Buendia MA. Transy C, et al. Proc Natl Acad Sci U S A. 1992 May 1;89(9):3874-8. doi: 10.1073/pnas.89.9.3874. Proc Natl Acad Sci U S A. 1992. PMID: 1570307 Free PMC article. - SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62.
Wang W, Liao P, Shen M, Chen T, Chen Y, Li Y, Lin X, Ge X, Wang P. Wang W, et al. Oncogene. 2016 Jan 28;35(4):491-500. doi: 10.1038/onc.2015.106. Epub 2015 Apr 20. Oncogene. 2016. PMID: 25893300 - Integration of papillomavirus DNA near myc genes in genital carcinomas and its consequences for proto-oncogene expression.
Couturier J, Sastre-Garau X, Schneider-Maunoury S, Labib A, Orth G. Couturier J, et al. J Virol. 1991 Aug;65(8):4534-8. doi: 10.1128/JVI.65.8.4534-4538.1991. J Virol. 1991. PMID: 1649348 Free PMC article. - Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors.
Wei Y, Fourel G, Ponzetto A, Silvestro M, Tiollais P, Buendia MA. Wei Y, et al. J Virol. 1992 Sep;66(9):5265-76. doi: 10.1128/JVI.66.9.5265-5276.1992. J Virol. 1992. PMID: 1323693 Free PMC article. - Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host.
Seeger C, Baldwin B, Hornbuckle WE, Yeager AE, Tennant BC, Cote P, Ferrell L, Ganem D, Varmus HE. Seeger C, et al. J Virol. 1991 Apr;65(4):1673-9. doi: 10.1128/JVI.65.4.1673-1679.1991. J Virol. 1991. PMID: 2002538 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources