Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study - PubMed (original) (raw)

Randomized Controlled Trial

Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study

Michelle L Headland et al. Int J Environ Res Public Health. 2019.

Abstract

Fibroblast growth factor-21 (FGF-21), is a protein involved in cell growth and differentiation, development, wound repair and metabolism. Research looking at the impact of weight loss on FGF-21 levels is limited. The objective of this exploratory study was to determine changes in serum FGF-21 levels following weight loss induced by either continuous energy restriction or intermittent energy restriction. A sub cohort of participants who completed a 12-month dietary intervention trial following continuous energy restriction, or a week-on week-off energy restriction pattern, were selected for analysis. FGF-21 levels were not altered by weight loss and were not correlated with body weight or BMI at baseline or 12 months. Weight loss after 12 months either through continuous energy restriction or intermittent energy restriction was -5.9 ± 4.5 and -4.9 ± 3.4 kg, respectively. There was no change in FGF-21 levels, 0.3 ± 0.9 and 0.04 ± 0.2 ng/mL (p = 0.2). In conclusion, weight loss in healthy overweight or obesity subjects did not affect FGF-21 levels.

Keywords: fibroblast growth factor-21; intermittent energy restriction; weight loss.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Owen B.M., Mangelsdorf D.J., Kliewer S.A. Tissue-specifc actions of the metabolic hormones FGF15/19 and FGF21. Trends Endocrinol. Metab. 2015;26:22–29. doi: 10.1016/j.tem.2014.10.002. - DOI - PMC - PubMed
    1. Angelin B., Larsson T.E., Rudling M. Circulating fibroblast growth factors as metabolic regulators—A cricitcal apprasial. Cell Metab. 2012;16:693–705. - PubMed
    1. Fisher F.M., Chiu P.C., Antonellis P.J., Bina H.A., Kharitonenkov A., Flier J.S., Maratos-Flier E. Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State. Diabetes. 2010;59:2781–2789. - PMC - PubMed
    1. Badman M.K., Pissios P., Kennedy A.R., Koukos G., Flier J.S., Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPAR-alpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007;5:426–437. doi: 10.1016/j.cmet.2007.05.002. - DOI - PubMed
    1. Inagaki T., Dutchak P., Zhao G., Ding X., Gautron L., Parameswara V., Li Y., Goetz R., Mohammadi M., Esser V., et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 2007;5:415–425. doi: 10.1016/j.cmet.2007.05.003. - DOI - PubMed

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