Beneficial Biological Activities of Cinnamomum osmophloeum and its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review - PubMed (original) (raw)

Review

Beneficial Biological Activities of Cinnamomum osmophloeum and its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review

Abu Bakar et al. Biomedicines. 2020.

Abstract

The aim of this review was to provide an updated overview of studies on the medical-biological activities of C_innamomum osmophloeum_ (C. osmophloeum) in vitro and in vivo and the potential therapeutic use of natural agents prepared from this plant for the alleviation of oral mucositis (OM). Reported articles were collected using web search engine tools. The systematic review was organized according to the preferred reporting items for reviews and meta-analyses (PRISMA) statement. Additional sources were identified through cross-referencing to identify the potential use of C. osmophloeum in the alleviation of OM. The results disclosed that C. osmophloeum is comprised of bioactive ingredients that could act diversely as a reagent in anti-inflammation, antibacterial, antioxidant, anti-hyperglycemic, antidyslipidemia, anti-cancer, renal disease therapy and anti-hyperuricemia capacities. Recent studies revealed that the overall effects on anti-inflammation, wound repair, and the antibacterial and antioxidant activities of its constituents would act as a potential remedy for oral mucositis. Up-to-date in vitro and in vivo studies on the medical-biological activities of C. osmophloeum suggested that C. osmophloeum and its constituents could be promising remedies as adjuvants in OM therapy and warrant further investigation.

Keywords: C. osmophloeum; biological activities; cinnamaldehyde; linalool; oral mucositis.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1

Figure 1

The systematic search for medical-biological activities of Cinnamomum osmophloeum.

Figure 2

Figure 2

Chemical structures of Cinnamomum osmophloeum chemotypes: (a) cinnamaldehyde, (b) cinnamyl acetate, (c) linalool, and (d) camphor.

Figure 3

Figure 3

Antibacterial properties of C. osmophloeum (A) and bacterial infection of oral mucositis (B).

Figure 4

Figure 4

Proposed potential use of C. osmophloeum in the alleviation of oral mucositis (OM). C. osmophloeum ameliorated oxidative stress and pro-inflammation through its constituents. Several studies have investigated the anti-inflammation, antibacterial, and antioxidant activities. The review of medical-biological activities showed that C. osmophloeum and its constituents inhibit the pro-inflammatory response. C. osmophloeum potentially prevents the second phase of oral mucositis (the primary damage response) or may intercept in the third phase, with pro-inflammatory cytokines providing a positive reaction to enhance and accelerate the process of wound healing. C. osmophloeum was also confirmed to be bactericidal and inhibit bacteria which can reduce the severity of oral mucositis or secondary bacterial infection.

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