GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits - PubMed (original) (raw)

doi: 10.1038/s41562-019-0805-1. Epub 2020 Jan 20.

Masato Akiyama 1 3, Kazuyoshi Ishigaki 1, Masahiro Kanai 1 4, Atsushi Takahashi 1 5, Yukihide Momozawa 6, Shiro Ikegawa 7, Masashi Ikeda 8, Nakao Iwata 8, Makoto Hirata 9, Koichi Matsuda 10, Yoshinori Murakami 11, Michiaki Kubo 12, Yoichiro Kamatani 13 14, Yukinori Okada 15 16 17

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GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits

Nana Matoba et al. Nat Hum Behav. 2020 Mar.

Abstract

Dietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human diseases. We performed genome-wide association studies for 13 dietary habits including consumption of alcohol (ever versus never drinkers and drinks per week), beverages (coffee, green tea and milk) and foods (yoghurt, cheese, natto, tofu, fish, small whole fish, vegetables and meat) in Japanese individuals (n = 58,610-165,084) collected by BioBank Japan, the nationwide hospital-based genome cohort. Significant associations were found in nine genetic loci (MCL1-ENSA, GCKR, AGR3-AHR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, CYP1A2-CSK and ADORA2A-AS1) for 13 dietary traits (P < 3.8 × 10-9). Of these, ten associations between five loci and eight traits were new findings. Furthermore, a phenome-wide association study revealed that five of the dietary trait-associated loci have pleiotropic effects on multiple human complex diseases and clinical measurements. Our findings provide new insight into the genetics of habitual consumption.

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