An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies - PubMed (original) (raw)

An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies

Shibo Jiang et al. Emerg Microbes Infect. 2020.

Erratum in

• Correction.
  Jiang S. Jiang S. Emerg Microbes Infect. 2020 Mar 5;9(1):539. doi: 10.1080/22221751.2020.1737363. eCollection 2020. Emerg Microbes Infect. 2020. PMID: 32134367 Free PMC article. No abstract available.

No abstract available

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Figures

Figure 1.

Analysis of the functional domains in 2019-nCoV spike protein and its gene. (A) Phylogenetic analysis of S gene of 2019-nCoV (Wuhan-Hu-1), bat-SL-CoVZXC21, bat-SL-CoVZXC45, SARS-CoV and other coronaviruses using Neighbor-Joining method. (B) The representative scheme of functional domains in S protein of 2019-nCoV. SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding domain; FP, fusion peptide, HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane domain; CP, cytoplasmic domain. (C) The target sites in 2019-nCoV S for development of vaccines, antibodies and fusion/entry inhibitors.

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