Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery - PubMed (original) (raw)

Fig. 6. Bile acid–fecal microbiota interactions.

a Bile acid transformation reactions. Orange color = primary bile acids, green = primary conjugated bile acids, blue = secondary bile acids, pink = secondary conjugated bile acids. CA cholic acid, DCA deoxycholic acid, GDCA glycodeoxycholic acid, TDCA taurodeoxycholic acid, GCA glycocholic acid, TCA taurocholic acid, CDCA chenodeoxycholic acid, LCA lithocholic acid, HCA hyacholic acid, HDCA hyodeoxycholic acid, UDCA ursodeoxycholic acid, GUDCA glycoursodeoxycholic acid, TUDCA tauroursodeoxycholic acid, THDCA taurohydroxydeoxycholic acid, GLCA glycolithocholic acid, TLCA taurolithocholic acid, GCDCA glycochenodeoxycholic acid, TCDCA taurochenodeoxycholic acid, αMCA α-muricholic acid, βMCA β-muricholic acid. b Bile acid biosynthesis genes predicted from 16S rRNA gene abundances via PICRUSt. KO numbers that were used in the prediction: K01442, K00076, K23231, K22604, K22605, K22606, K22607, K15868, K15871, K15869, K15870, K15873, K15874, and K07007. The box plots represent minimum, maximum, median, first quartile, and third quartile values. c Fecal bile acid and microbiome co-occurrence network based on Spearman’s rho correlation coefficients.