Cellular responses to combinations of hyperthermia and radiation - PubMed (original) (raw)

Review

. 1977 May;123(2):463-74.

doi: 10.1148/123.2.463.

Review

Cellular responses to combinations of hyperthermia and radiation

W C Dewey et al. Radiology. 1977 May.

Abstract

The two principal rationales for applying hyperthermia in cancer therapy are that: (a) the S phase, which is relatively radioresistant, is the most sensitive phase to hyperthermia, and can be selectively radiosensitized by combining hyperthermia with x-irradiation; the cycling tumor cells in S phase which would normally survive an x-ray dose could thus be killed by subjecting these cells to hyperthermia; and (b) the relatively radioresistant hypoxic cells in the tumor may be selectively destroyed by combinations of hyperthermia and x-irradiation. Both of these rationales have been mentioned as reasons for using high LET irradiation in cancer therapy; therefore where such irradiation may be of use, hyperthermia may also be advantageous.

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