Therapeutic strategies for critically ill patients with COVID-19 - PubMed (original) (raw)

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Therapeutic strategies for critically ill patients with COVID-19

Lei Li et al. Ann Intensive Care. 2020.

Abstract

Since the 2019 novel coronavirus disease (COVID-19) outbreak originated from Wuhan, Hubei Province, China, at the end of 2019, it has become a clinical threat to the general population worldwide. Among people infected with the novel coronavirus (2019-nCoV), the intensive management of the critically ill patients in intensive care unit (ICU) needs substantial medical resource. In the present article, we have summarized the promising drugs, adjunctive agents, respiratory supportive strategies, as well as circulation management, multiple organ function monitoring and appropriate nutritional strategies for the treatment of COVID-19 in the ICU based on the previous experience of treating other viral infections and influenza. These treatments are referable before the vaccine and specific drugs are available for COVID-19.

Keywords: 2019-nCoV; Adjunctive intervention; Antiviral therapy; Coronavirus; Respiratory support.

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Conflict of interest statement

The authors declare that they have no competing interests.

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References

1. 1. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733. doi: 10.1056/NEJMoa2001017. - DOI - PMC - PubMed
2. 1. Organization WH. clinical-management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected-interim guidance. Published January 28, 2020.
3. 1. Qiu H, Tong Z, Ma P, et al. Intensive care during the coronavirus epidemic. Intensive Care Med. 2020 doi: 10.1007/s00134-020-05966-y. - DOI - PMC - PubMed
4. 1. Hui DS, Azhar I, Madani TA, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—the latest, novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2019;2020(91):264–266. - PMC - PubMed
5. 1. Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565–574. doi: 10.1016/S0140-6736(20)30251-8. - DOI - PMC - PubMed

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