Diagnostic accuracy of FibroScan-AST score to identify non-alcoholic steatohepatitis with significant activity and fibrosis in Japanese patients with non-alcoholic fatty liver disease: Comparison between M and XL probes - PubMed (original) (raw)

. 2020 Jul;50(7):831-839.

doi: 10.1111/hepr.13508. Epub 2020 May 13.

Hirokazu Takahashi 3, Kento Imajo 4, Yuya Seko 5, Takashi Kobayashi 4, Yuji Ogawa 4, Michihisa Moriguchi 5, Masato Yoneda 4, Keizo Anzai 3, Hiroyuki Irie 6, Eisaburo Sueoka 2 7, Shinichi Aishima 8, Masayoshi Kage 9, Yoshito Itoh 5, Yuichiro Eguchi 1, Atsushi Nakajima 4

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Diagnostic accuracy of FibroScan-AST score to identify non-alcoholic steatohepatitis with significant activity and fibrosis in Japanese patients with non-alcoholic fatty liver disease: Comparison between M and XL probes

Satoshi Oeda et al. Hepatol Res. 2020 Jul.

Abstract

Aim: Recently, FibroScan-AST (FAST) score was reported to be effective for identifying non-alcoholic steatohepatitis (NASH) with significant activity and fibrosis in non-alcoholic fatty liver disease (NAFLD). The aim of this study was to confirm the diagnostic accuracy of FAST score of Japanese patients and compare the cut-off values and diagnostic accuracy between the FibroScan M and XL probes.

Methods: Eighty-two and 84 patients were included the verification and validation sets, respectively. All patients were diagnosed with NAFLD by biopsy by two central expert pathologists. Liver stiffness measurements and controlled attenuation parameter were carried out, and diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis.

Results: No significant difference existed in FAST score between the M and XL probes (0.489 vs. 0.483, P = 0.187). No significant difference existed in the area under the ROC between the two probes (M, 0.7598; XL, 0.7614; P = 0.958). According to the Youden index, the cut-off value using the M probe was 0.57 with 68.2% sensitivity and 78.3% specificity. For the XL probe, the cut-off value was 0.56 with 68.2% sensitivity and 73.3% specificity. To obtain sensitivity and specificity values higher than 90%, cut-off values of 0.35 and 0.66 were chosen for the M probe and 0.32 and 0.63 were chosen for the XL probe.

Conclusions: There was no significant difference in diagnostic accuracy of FAST score between the FibroScan M and XL probes. The FAST score can be used to identify NASH with significant risk in Japanese patients regardless of probe selection.

Keywords: elastography; fibrosis; non-alcoholic fatty liver disease activity score; non-alcoholic steatohepatitis; steatosis.

©2020 The Japan Society of Hepatology.

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