The multiple roles of Thy-1 in cell differentiation and regeneration - PubMed (original) (raw)

Review

. 2020 May-Jun:113:38-48.

doi: 10.1016/j.diff.2020.03.003. Epub 2020 Apr 8.

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Review

The multiple roles of Thy-1 in cell differentiation and regeneration

Jie Yang et al. Differentiation. 2020 May-Jun.

Abstract

Thy-1 is a 25-37 kDa glycophosphatidylinositol (GPI)-anchored cell surface protein that was discovered more than 50 years ago. Recent findings have suggested that Thy-1 is expressed on thymocytes, mesenchymal stem cells (MSCs), cancer stem cells, hematopoietic stem cells, fibroblasts, myofibroblasts, endothelial cells, neuronal smooth muscle cells, and pan T cells. Thy-1 plays vital roles in cell migration, adhesion, differentiation, transdifferentiation, apoptosis, mechanotransduction, and cell division, which in turn are involved in tumor development, pulmonary fibrosis, neurite outgrowth, and T cell activation. Studies have increasingly indicated a significant role of Thy-1 in cell differentiation and regeneration. However, despite recent research, many questions remain regarding the roles of Thy-1 in cell differentiation and regeneration. This review aimed to summarize the roles of Thy-1 in cell differentiation and regeneration. Furthermore, since Thy-1 is an outer leaflet membrane protein anchored by GPI, we attempted to address how Thy-1 regulates intracellular pathways through cis and trans signals. Due to the complexity and mystery surrounding the issue, we also summarized the Thy-1-related pathways in different biological processes, and this might provide novel insights in the field of cell differentiation and regeneration.

Keywords: Differentiation; Integrins; Regeneration; SFKs; Signaling pathways; Thy-1.

Copyright © 2020. Published by Elsevier B.V.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflicts of interest.

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