Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut - PubMed (original) (raw)

. 2020 Jun 11;181(6):1307-1328.e15.

doi: 10.1016/j.cell.2020.04.049. Epub 2020 Jun 4.

Affiliations

• PMID: 32502393
• DOI: 10.1016/j.cell.2020.04.049

Free article

Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut

Alexandra Vaccaro et al. Cell. 2020.

Free article

Abstract

The view that sleep is essential for survival is supported by the ubiquity of this behavior, the apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep loss can be lethal. The cause of this lethality is unknown. Here we show, using flies and mice, that sleep deprivation leads to accumulation of reactive oxygen species (ROS) and consequent oxidative stress, specifically in the gut. ROS are not just correlates of sleep deprivation but drivers of death: their neutralization prevents oxidative stress and allows flies to have a normal lifespan with little to no sleep. The rescue can be achieved with oral antioxidant compounds or with gut-targeted transgenic expression of antioxidant enzymes. We conclude that death upon severe sleep restriction can be caused by oxidative stress, that the gut is central in this process, and that survival without sleep is possible when ROS accumulation is prevented. VIDEO ABSTRACT.

Keywords: antioxidants; free radicals; gut; oxidative stress; reactive oxygen species; sleep; sleep deprivation; survival.

Copyright © 2020 Elsevier Inc. All rights reserved.

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Conflict of interest statement

Declaration of Interests A patent to A.V. and D.R. is pending (“A method for treating damage induced by sleep deprivation”).

Comment in

• Sleep loss lethality is caused by gut ROS in mice and flies.
  Hindson J. Hindson J. Nat Rev Gastroenterol Hepatol. 2020 Aug;17(8):452. doi: 10.1038/s41575-020-0340-6. Nat Rev Gastroenterol Hepatol. 2020. PMID: 32612267 No abstract available.
• Sleep deficiency and mortality: is the solution in the gut?
  Nakada Y, Sadoshima J. Nakada Y, et al. Cardiovasc Res. 2021 Jan 21;117(2):e26-e28. doi: 10.1093/cvr/cvaa309. Cardiovasc Res. 2021. PMID: 33179722 Free PMC article. No abstract available.

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