Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ - PubMed (original) (raw)
Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ
A G Lumsden. Development. 1988.
Abstract
Teeth develop from composite organ rudiments that are formed through the interaction of oral epithelium and mesenchyme of the first branchial arch; cells of the former differentiate into enamel-secreting ameloblasts whereas those of the latter differentiate into dentine-secreting odontoblasts. Experimental analysis of odontogenic tissue interactions in mammalian embryos has focused on the late developmental stages of morphogenesis and cytodifferentiation; little is known about initial pattern-forming events, during which presumptive tooth-forming cells are specified and the sites of tooth initiation become established. It requires to be shown, for example, whether the mesenchymal cells of mammalian teeth are derived, like those of amphibians, from the cranial neural crest, and if so, whether these form a specified subpopulation in the neural folds. Alternatively, are they specified after migration into the mandibular arch, possibly by interaction with the oral epithelium? The developmental potentials of mouse embryo premigratory cranial neural crest cells (CNC - explanted from the caudal mesencephalic and rostral metencephalic neural folds) have been studied in intraocular homograft recombinations with various regions of embryonic surface ectoderm. Cartilage, bone and neural tissue developed in all combinations of CNC and epithelium. Teeth formed in combinations of CNC with mandibular arch epithelium but not in combinations of CNC with limb bud epithelium. Teeth also formed in combinations of mandibular arch epithelium with neural crest explanted from the trunk level. These results indicate that mammalian neural crest has an odontogenic potential but that this is not restricted to the crest of presumptive tooth-forming levels. Normal migration appears not to be a prerequisite for expression of odontogenic potential but this does require an interaction with region-specific epithelium. It is reasonable to infer that during normal development the neural crest that enters the mandibular arch is odontogenically unspecified before or during migration and that the oral epithelium is the earliest known site of tooth pattern.
Similar articles
- Timing of odontogenic neural crest cell migration and tooth-forming capability in mice.
Zhang Y, Wang S, Song Y, Han J, Chai Y, Chen Y. Zhang Y, et al. Dev Dyn. 2003 Apr;226(4):713-8. doi: 10.1002/dvdy.10274. Dev Dyn. 2003. PMID: 12666208 - Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation.
Thesleff I, Keränen S, Jernvall J. Thesleff I, et al. Adv Dent Res. 2001 Aug;15:14-8. doi: 10.1177/08959374010150010401. Adv Dent Res. 2001. PMID: 12640732 Review. - Contributions of heterospecific tissue recombinations to odontogenesis.
Lemus D. Lemus D. Int J Dev Biol. 1995 Feb;39(1):291-7. Int J Dev Biol. 1995. PMID: 7626419 Review. - The induction of odontogenesis in non-dental mesenchyme combined with early murine mandibular arch epithelium.
Mina M, Kollar EJ. Mina M, et al. Arch Oral Biol. 1987;32(2):123-7. doi: 10.1016/0003-9969(87)90055-0. Arch Oral Biol. 1987. PMID: 3478009 - Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis.
Chai Y, Jiang X, Ito Y, Bringas P Jr, Han J, Rowitch DH, Soriano P, McMahon AP, Sucov HM. Chai Y, et al. Development. 2000 Apr;127(8):1671-9. doi: 10.1242/dev.127.8.1671. Development. 2000. PMID: 10725243
Cited by
- A transcriptomic analysis of dental pulp stem cell senescence in vitro.
Xu J, Hu M, Liu L, Xu X, Xu L, Song Y. Xu J, et al. Biomed Eng Online. 2024 Oct 18;23(1):102. doi: 10.1186/s12938-024-01298-w. Biomed Eng Online. 2024. PMID: 39425139 Free PMC article. - The Differentiation Potential of Apical Papilla Cells in Relation to Tenascin-C and Syndecan-1 Expression and Their Potential Role in Regeneration.
Kodonas K, Fardi A, Papadimitriou S, Gogos C. Kodonas K, et al. Int J Dent. 2024 Sep 20;2024:7295498. doi: 10.1155/2024/7295498. eCollection 2024. Int J Dent. 2024. PMID: 39345930 Free PMC article. - Spatial and temporal gene expression patterns during early human odontogenesis process.
Yu Y, Wang K, Wang Z, Cai H, Liao C, Wu Y, Zhang J, Tian W, Liao L. Yu Y, et al. Front Bioeng Biotechnol. 2024 Jul 16;12:1437426. doi: 10.3389/fbioe.2024.1437426. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 39081334 Free PMC article. - Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation.
Shao F, Phan AV, Yu W, Guo Y, Thompson J, Coppinger C, Venugopalan SR, Amendt BA, Van Otterloo E, Cao H. Shao F, et al. PLoS Genet. 2024 Jul 25;20(7):e1011364. doi: 10.1371/journal.pgen.1011364. eCollection 2024 Jul. PLoS Genet. 2024. PMID: 39052671 Free PMC article. - Potential of dental pulp stem cells and their products in promoting peripheral nerve regeneration and their future applications.
Xing WB, Wu ST, Wang XX, Li FY, Wang RX, He JH, Fu J, He Y. Xing WB, et al. World J Stem Cells. 2023 Oct 26;15(10):960-978. doi: 10.4252/wjsc.v15.i10.960. World J Stem Cells. 2023. PMID: 37970238 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources