Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells - PubMed (original) (raw)

Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells

A McInnes et al. J Exp Med. 1988.

Abstract

Giant multinucleated cells (GMCs) are associated with granulomatous lesions that form in response to various infectious and noninfectious agents. The present study shows that mouse IL-4 induces the in vitro formation of GMCs by factor-dependent bone marrow and alveolar monocytes via cell fusion. GMCs appear 2 d after incubation of cell cultures with 20 U/ml or more of IL-4. Anti-IL-4 mAbs block the appearance of GMCs in these cultures, indicating that IL-4 acts directly on monocytes to promote fusion and does not secondarily induce the production of other soluble fusion factors. In soft agar cultures, IL-4 also causes the aggregation of macrophages and diminishes their migration. The role of IL-4 in a granulomatous inflammatory response is discussed.

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References

1. 1. J Immunol. 1977 Jun;118(6):2015-9 - PubMed
2. 1. Am J Pathol. 1976 Jul;84(1):164-92 - PubMed
3. 1. J Pathol. 1977 Oct;123(2):65-77 - PubMed
4. 1. J Immunol. 1978 Mar;120(3):1054-62 - PubMed
5. 1. Gut. 1978 Jun;19(6):572-7 - PubMed

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