Nonoxidative glucose consumption during focal physiologic neural activity - PubMed (original) (raw)
. 1988 Jul 22;241(4864):462-4.
doi: 10.1126/science.3260686.
Affiliations
- PMID: 3260686
- DOI: 10.1126/science.3260686
Nonoxidative glucose consumption during focal physiologic neural activity
P T Fox et al. Science. 1988.
Abstract
Brain glucose uptake, oxygen metabolism, and blood flow in humans were measured with positron emission tomography, and a resting-state molar ratio of oxygen to glucose consumption of 4.1:1 was obtained. Physiological neural activity, however, increased glucose uptake and blood flow much more (51 and 50 percent, respectively) than oxygen consumption (5 percent) and produced a molar ratio for the increases of 0.4:1. Transient increases in neural activity cause a tissue uptake of glucose in excess of that consumed by oxidative metabolism, acutely consume much less energy than previously believed, and regulate local blood flow for purposes other than oxidative metabolism.
Similar articles
- Brain energy metabolism in early blind subjects: neural activity in the visual cortex.
De Volder AG, Bol A, Blin J, Robert A, Arno P, Grandin C, Michel C, Veraart C. De Volder AG, et al. Brain Res. 1997 Mar 7;750(1-2):235-44. doi: 10.1016/s0006-8993(96)01352-2. Brain Res. 1997. PMID: 9098549 - Dynamic NMR studies of perfusion and oxidative metabolism during focal brain activation.
Frahm J, Krueger G, Merboldt KD, Kleinschmidt A. Frahm J, et al. Adv Exp Med Biol. 1997;413:195-203. doi: 10.1007/978-1-4899-0056-2_21. Adv Exp Med Biol. 1997. PMID: 9238500 Clinical Trial. - Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.
Magistretti PJ, Pellerin L. Magistretti PJ, et al. Philos Trans R Soc Lond B Biol Sci. 1999 Jul 29;354(1387):1155-63. doi: 10.1098/rstb.1999.0471. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10466143 Free PMC article. Review. - Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man.
Frahm J, Krüger G, Merboldt KD, Kleinschmidt A. Frahm J, et al. Magn Reson Med. 1996 Feb;35(2):143-8. doi: 10.1002/mrm.1910350202. Magn Reson Med. 1996. PMID: 8622575 - Oxidative metabolism and the detection of neuronal activation via imaging.
Hoge RD, Pike GB. Hoge RD, et al. J Chem Neuroanat. 2001 Jul;22(1-2):43-52. doi: 10.1016/s0891-0618(01)00114-4. J Chem Neuroanat. 2001. PMID: 11470553 Review.
Cited by
- Cell-specific expression of key mitochondrial enzymes limits OXPHOS in astrocytes of the adult human neocortex and hippocampal formation.
Dobolyi A, Cservenák M, Bagó AG, Chen C, Stepanova A, Paal K, Lee J, Palkovits M, Hudson G, Chinopoulos C. Dobolyi A, et al. Commun Biol. 2024 Aug 24;7(1):1045. doi: 10.1038/s42003-024-06751-z. Commun Biol. 2024. PMID: 39181993 Free PMC article. - Adenosine signalling to astrocytes coordinates brain metabolism and function.
Theparambil SM, Kopach O, Braga A, Nizari S, Hosford PS, Sagi-Kiss V, Hadjihambi A, Konstantinou C, Esteras N, Gutierrez Del Arroyo A, Ackland GL, Teschemacher AG, Dale N, Eckle T, Andrikopoulos P, Rusakov DA, Kasparov S, Gourine AV. Theparambil SM, et al. Nature. 2024 Aug;632(8023):139-146. doi: 10.1038/s41586-024-07611-w. Epub 2024 Jul 3. Nature. 2024. PMID: 38961289 Free PMC article. - Organ-Specific Mitochondrial Alterations Following Ischemia-Reperfusion Injury in Post-Cardiac Arrest Syndrome: A Comprehensive Review.
Nakamura E, Aoki T, Endo Y, Kazmi J, Hagiwara J, Kuschner CE, Yin T, Kim J, Becker LB, Hayashida K. Nakamura E, et al. Life (Basel). 2024 Apr 5;14(4):477. doi: 10.3390/life14040477. Life (Basel). 2024. PMID: 38672748 Free PMC article. Review. - How Much Energy Do E'Athletes Use during Gameplay? Quantifying Energy Expenditure and Heart Rate Variability Within E'Athletes.
Nicholson M, Poulus D, Robergs R, Kelly V, McNulty C. Nicholson M, et al. Sports Med Open. 2024 Apr 17;10(1):44. doi: 10.1186/s40798-024-00708-6. Sports Med Open. 2024. PMID: 38630170 Free PMC article. - How the 'Aerobic/Anaerobic Glycolysis' Meme Formed a 'Habit of Mind' Which Impedes Progress in the Field of Brain Energy Metabolism.
Schurr A. Schurr A. Int J Mol Sci. 2024 Jan 24;25(3):1433. doi: 10.3390/ijms25031433. Int J Mol Sci. 2024. PMID: 38338711 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources