The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens - PubMed (original) (raw)
. 1988 Oct 27;335(6193):796-801.
doi: 10.1038/335796a0.
Affiliations
- PMID: 3263572
- DOI: 10.1038/335796a0
The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens
A M Pullen et al. Nature. 1988.
Abstract
T cells with V beta 3+ alpha beta receptors are deleted by self-tolerance in mice with particular major histocompatibility complex/self-antigen combinations. This also occurs for other V beta elements. Polymorphism in the major histocompatibility complex and/or the self-antigens that cause massive deletion of T cells using particular V beta elements may be maintained by the need to balance the advantage of a diverse T-cell repertoire against the potential involvement of those elements in autoimmune disease.
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