Development of follicular dendritic cells in lymph nodes of B-cell-depleted mice - PubMed (original) (raw)

. 1988 Nov;254(2):449-54.

doi: 10.1007/BF00225818.

Affiliations

• PMID: 3264209
• DOI: 10.1007/BF00225818

Development of follicular dendritic cells in lymph nodes of B-cell-depleted mice

A Cerny et al. Cell Tissue Res. 1988 Nov.

Abstract

We have studied follicular dendritic cells (FDC) in lymph nodes of normal and thymus dysgeneic nude mice depleted of B-cells by chronic treatment with anti-IgM antibodies. We found that B cell depletion was accompanied by the absence of mature FDC as defined morphologically at the ultrastructural level. Only precursor FDC (p-FDC) could be demonstrated. Upon release of B-cell suppression, the repopulation of lymph nodes with B-cells was associated with the reappearance of fully differentiated FDC in primary follicles of nude mice and in secondary follicles of T-cell competent mice. We conclude that mature B-cells and/or B-cell products are required for the development of mature follicular dendritic cells in the mouse lymph node.

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