Non-alcoholic fatty liver disease: A review with clinical and pathological correlation - PubMed (original) (raw)

Review

. 2021 Jan;120(1 Pt 1):68-77.

doi: 10.1016/j.jfma.2020.07.006. Epub 2020 Jul 9.

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Review

Non-alcoholic fatty liver disease: A review with clinical and pathological correlation

Yen-Ying Chen et al. J Formos Med Assoc. 2021 Jan.

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in North America and Europe, with increasing prevalence in other regions of the world. Its spectrum encompass steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. It is considered as the manifestation of metabolic syndrome in liver, and its development and progression is influenced by complex interaction of environmental and genetic factors. In this review we discuss the histopathological features, differential diagnoses, and the commonly used grading and staging systems of NAFLD. NAFLD associated with other diseases, histological changes after therapeutic intervention and recurrence or occurrence of NAFLD after liver transplantation are also addressed.

Keywords: Fatty liver; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis.

Copyright © 2020. Published by Elsevier B.V.

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Declaration of Competing Interest The authors have no conflicts of interest relevant to this article.

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