Human Infection Challenge Studies: a Test for the Social Value Criterion of Research Ethics - PubMed (original) (raw)

Human Infection Challenge Studies: a Test for the Social Value Criterion of Research Ethics

Nicholas G Evans. mSphere. 2020.

Abstract

Human infection challenge studies involving the intentional infection of research participants with a disease-causing agent have recently been suggested as a means to speed up the search for a vaccine for the ongoing coronavirus disease 2019 (COVID-19) outbreak. Calls for challenge studies, however, rely on the expected social value of these studies. This value represents more than the simple possibility that a successful study will lead to the rapid development and dissemination of vaccines but also some expectation that this will actually occur. I show how this expectation may not be realistic in the current political moment and offer potential ways to make sure that any challenge trials that arise actually achieve their goals.

Keywords: COVID-19; challenge studies; coronavirus; global health; research ethics.

Copyright © 2020 Evans.

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References

    1. Eyal N, Lipsitch M, Smith PG. 2020. Human challenge studies to accelerate coronavirus vaccine licensure. J Infect Dis 221:1752–1756. doi: 10.1093/infdis/jiaa152. -DOI -PMC -PubMed
    1. Shah SK, Miller FG, Darton TC, Duenas D, Emerson C, Lynch HF, Jamrozik E, Jecker NS, Kamuya D, Kapulu M, Kimmelman J, MacKay D, Memoli MJ, Murphy SC, Palacios R, Richie TL, Roestenberg M, Saxena A, Saylor K, Selgelid MJ, Vaswani V, Rid A. 2020. Ethics of controlled human infection to address COVID-19. Science 368:832–834. doi: 10.1126/science.abc1076. -DOI -PubMed
    1. Jamrozik E, Selgelid MJ. 2020. COVID-19 human challenge studies: ethical issues. Lancet Infect Dis doi: 10.1016/S1473-3099(20)30438-2. -DOI -PMC -PubMed
    1. Miller FG, Grady C. 2001. The ethical challenge of infection-inducing challenge experiments. Clin Infect Dis 33:1028–1033. doi: 10.1086/322664. -DOI -PubMed
    1. Tyrrell D. 1992. A view from the common cold unit. Antiviral Res 18:105–125. doi: 10.1016/0166-3542(92)90032-Z. -DOI -PMC -PubMed

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