A deletion mutant of L-A double-stranded RNA replicates like M1 double-stranded RNA - PubMed (original) (raw)
Comparative Study
A deletion mutant of L-A double-stranded RNA replicates like M1 double-stranded RNA
R Esteban et al. J Virol. 1988 Apr.
Abstract
X double-stranded RNA (dsRNA) is a 0.52-kilobase dsRNA molecule that arose spontaneously in a nonkiller strain of Saccharomyces cerevisiae originally containing L-A and L-BC dsRNAs (L-BC is the same size as L-A but shares no homology with it). X hybridized with L-A, and direct RNA sequencing of X showed that the first 5' 25 base pairs (of the X positive strand) and at least the last 110 base pairs of the 3' end were identical to the ends of L-A dsRNA. X showed cytoplasmic inheritance and, like M1, was dependent on L-A for its maintenance. X was encapsidated in viruslike particles whose major coat protein was provided by L-A (as is true for M1), and X was found in viruslike particles with one to eight X molecules per particle. This finding confirms our "head-full replication" model originally proposed for M1 and M2. Like M1 or M2, X lowers the copy number of L-A, especially in a ski host. Surprisingly, X requires many chromosomal MAK genes that are necessary for M1 but not for L-A.
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References
- Microbiol Rev. 1987 Jun;51(2):179-91 - PubMed
- Nucleic Acids Res. 1980 Jun 11;8(11):2349-63 - PubMed
- J Bacteriol. 1978 Dec;136(3):1002-7 - PubMed
- Genetics. 1973 Aug;74(4):571-9 - PubMed
- Mol Cell Biol. 1984 Jan;4(1):92-100 - PubMed
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