A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides - PubMed (original) (raw)
. 1988 Apr 28;332(6167):800-5.
doi: 10.1038/332800a0.
Affiliations
- PMID: 3282178
- DOI: 10.1038/332800a0
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
R J Deshaies et al. Nature. 1988.
Abstract
Depletion of a subset of 70K stress proteins in yeast mutants shows that they are involved in the post-translational import of precursor polypeptides into both mitochondria and the lumen of the endoplasmic reticulum. The identification of such a basic function may explain the remarkable evolutionary conservation of the gene family encoding these proteins.
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