Short-Term Ketogenic Diet Improves Abdominal Obesity in Overweight/Obese Chinese Young Females - PubMed (original) (raw)

Short-Term Ketogenic Diet Improves Abdominal Obesity in Overweight/Obese Chinese Young Females

Zhaowei Kong et al. Front Physiol. 2020.

Abstract

The purpose of this study was to examine the effects of a short-term ketogenic diet (KD) on body composition and cardiorespiratory fitness (CRF) in overweight/obese Chinese females. Twenty young females [age: 21.0 ± 3.7 years, weight: 65.5 ± 7.7 kg, body mass index (BMI): 24.9 ± 2.7 kg⋅m-2] consumed 4 weeks of a normal diet (ND) as a baseline and then switched to a low-carbohydrate, high-fat, and adequate protein KD for another 4 weeks. With the same daily caloric intake, the proportions of energy intake derived from carbohydrates, proteins, and fats were changed from 44.0 ± 7.6%, 15.4 ± 3.3%, 39.6 ± 5.8% in ND to 9.2 ± 4.8%, 21.9 ± 3.4%, and 69.0 ± 5.4% in KD. The results showed that, without impairing the CRF level, the 4-week KD intervention significantly reduced body weight (-2.9 kg), BMI (-1.1 kg⋅m-2), waist circumference (-4.0 cm), hip circumference (-2.5 cm), and body fat percentage (-2.0%). Moreover, fasting leptin level was lowered significantly, and serum levels of inflammatory markers (i.e., TNF-α and MCP-1) were unchanged following KD. These findings suggest that KD can be used as a rapid and effective approach to lose weight and reduce abdominal adiposity in overweight/obese Chinese females without exacerbating their CRF.

Keywords: cardiorespiratory fitness; leptin; low-carbohydrate; subcutaneous fat; weight loss.

Copyright © 2020 Kong, Sun, Shi, Zhang, Tong and Nie.

PubMed Disclaimer

Figures

FIGURE 1

FIGURE 1

Flow-chart of the study.

FIGURE 2

FIGURE 2

Daily energy intake (A), proportions of carbohydrate (B), protein (C), and fat (D) intakes during normal diet (ND) and ketogenic diet (KD). Compared to week 1 of ND at a p < 0.01; compared to week 2 of ND at b p < 0.01; compared to week 3 of ND at c p < 0.01; compared to week 4 of ND at d p < 0.01.

References

    1. Ahima R. S., Flier J. S. (2000). Leptin. Ann. Rev. Physiol. 62 413–437. - PubMed
    1. Almallah M. H., Sakr S., Alqunaibet A. (2018). Cardiorespiratory fitness and cardiovascular disease prevention: an update. Curr. Atherosc. Rep. 20 1–9. - PubMed
    1. Boden G., Sargrad K., Homko C., Mozzoli M., Stein T. P. (2005). Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes. Ann. Int. Med. 142 403–411. - PubMed
    1. Brinkworth G. D., Noakes M., Buckley J. D., Keogh J. B., Clifton P. M. (2009a). Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo. Am. J. Clin. Nutr. 90 23–32. 10.3945/ajcn.2008.27326 - DOI - PubMed
    1. Brinkworth G. D., Noakes M., Clifton P. M., Buckley J. D. (2009b). Effects of a low carbohydrate weight loss diet on exercise capacity and tolerance in obese subjects. Obesity 17 1916–1923. 10.1038/oby.2009.134 - DOI - PubMed

LinkOut - more resources