Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera - PubMed (original) (raw)
Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera
M G Roncarolo et al. J Exp Med. 1988.
Abstract
T cell clones of donor origin that specifically react with recipient cells were obtained from a SCID patient successfully reconstituted by allogeneic fetal liver and thymus transplantation performed 10 yr ago. The majority of these clones displayed both cytotoxic and proliferative responses towards PBL and an EBV-transformed B cell line derived from the patient. In addition, these T cell clones had proliferative and cytotoxic responses towards the parental PBL, EBV cell lines, and PHA blasts. Blocking studies with anti-class I and anti-class II HLA mAbs indicated that the activity of the CD4+ T cell clones was specifically directed against class II HLA antigens of the recipient. On the other hand, the cytotoxic and proliferative responses of the CD8+ T cell clones were specific for class I HLA antigens which are ubiquitously expressed on the recipient cells. Thus, the establishment of transplantation tolerance observed in this stable human chimera is not due to the elimination of host-reactive T cells from the repertoire and suggests the presence of a peripheral autoregulatory suppressor mechanism.
Similar articles
- Antigen recognition by MHC-incompatible cells of a human mismatched chimera.
Roncarolo MG, Yssel H, Touraine JL, Bacchetta R, Gebuhrer L, De Vries JE, Spits H. Roncarolo MG, et al. J Exp Med. 1988 Dec 1;168(6):2139-52. doi: 10.1084/jem.168.6.2139. J Exp Med. 1988. PMID: 2462006 Free PMC article. - T cell repertoire and tolerance after fetal stem cell transplantation.
Roncarolo MG, Bacchetta R. Roncarolo MG, et al. Bone Marrow Transplant. 1992;9 Suppl 1:127-8. Bone Marrow Transplant. 1992. PMID: 1354521 - Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus.
Vandekerckhove BA, Namikawa R, Bacchetta R, Roncarolo MG. Vandekerckhove BA, et al. J Exp Med. 1992 Apr 1;175(4):1033-43. doi: 10.1084/jem.175.4.1033. J Exp Med. 1992. PMID: 1348080 Free PMC article. - Presence of host-reactive and MHC-restricted T cells in a transplanted severe combined immunodeficient (SCID) patient suggest positive selection and absence of clonal deletion.
Spits H, Touraine JL, Yssel H, de Vries JE, Roncarolo MG. Spits H, et al. Immunol Rev. 1990 Aug;116:101-16. doi: 10.1111/j.1600-065x.1990.tb00806.x. Immunol Rev. 1990. PMID: 2227991 Review. No abstract available.
Cited by
- Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion.
Whiteside SK, Grant FM, Alvisi G, Clarke J, Tang L, Imianowski CJ, Zhang B, Evans AC, Wesolowski AJ, Conti AG, Yang J, Lauder SN, Clement M, Humphreys IR, Dooley J, Burton O, Liston A, Alloisio M, Voulaz E, Langhorne J, Okkenhaug K, Lugli E, Roychoudhuri R. Whiteside SK, et al. Sci Immunol. 2023 Dec 15;8(90):eabo5558. doi: 10.1126/sciimmunol.abo5558. Epub 2023 Dec 15. Sci Immunol. 2023. PMID: 38100544 Free PMC article. - Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells.
Angelats E, Santamaria P. Angelats E, et al. Front Immunol. 2023 Sep 25;14:1267697. doi: 10.3389/fimmu.2023.1267697. eCollection 2023. Front Immunol. 2023. PMID: 37818381 Free PMC article. Review. - Intestinal Tr1 Cells Confer Protection against Colitis in the Absence of Foxp3+ Regulatory T Cell-Derived IL-10.
Zhou JY, Glendenning LM, Cavanaugh JM, McNeer SK, Goodman WA, Cobb BA. Zhou JY, et al. Immunohorizons. 2023 Jun 1;7(6):456-466. doi: 10.4049/immunohorizons.2200071. Immunohorizons. 2023. PMID: 37314833 Free PMC article. - Highly purified and functionally stable in vitro expanded allospecific Tr1 cells expressing immunosuppressive graft-homing receptors as new candidates for cell therapy in solid organ transplantation.
Arteaga-Cruz S, Cortés-Hernández A, Alvarez-Salazar EK, Rosas-Cortina K, Aguilera-Sandoval C, Morales-Buenrostro LE, Alberú-Gómez JM, Soldevila G. Arteaga-Cruz S, et al. Front Immunol. 2023 Feb 24;14:1062456. doi: 10.3389/fimmu.2023.1062456. eCollection 2023. Front Immunol. 2023. PMID: 36911743 Free PMC article. - Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease.
Jacobse J, Li J, Rings EHHM, Samsom JN, Goettel JA. Jacobse J, et al. Front Immunol. 2021 Aug 4;12:716499. doi: 10.3389/fimmu.2021.716499. eCollection 2021. Front Immunol. 2021. PMID: 34421921 Free PMC article. Review.
References
- J Exp Med. 1978 Mar 1;147(3):882-96 - PubMed
- Hum Immunol. 1987 Jul;19(3):189-203 - PubMed
- J Immunol. 1980 Oct;125(4):1421-5 - PubMed
- Hum Immunol. 1981 Mar;2(2):147-53 - PubMed
- Transplantation. 1982 May;33(5):510-4 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials