Specification of cerebral cortical areas - PubMed (original) (raw)
Review
. 1988 Jul 8;241(4862):170-6.
doi: 10.1126/science.3291116.
Affiliations
- PMID: 3291116
- DOI: 10.1126/science.3291116
Review
Specification of cerebral cortical areas
P Rakic. Science. 1988.
Abstract
How the immense population of neurons that constitute the human cerebral neocortex is generated from progenitors lining the cerebral ventricle and then distributed to appropriate layers of distinctive cytoarchitectonic areas can be explained by the radial unit hypothesis. According to this hypothesis, the ependymal layer of the embryonic cerebral ventricle consists of proliferative units that provide a proto-map of prospective cytoarchitectonic areas. The output of the proliferative units is translated via glial guides to the expanding cortex in the form of ontogenetic columns, whose final number for each area can be modified through interaction with afferent input. Data obtained through various advanced neurobiological techniques, including electron microscopy, immunocytochemistry, [3H]thymidine and receptor autoradiography, retrovirus gene transfer, neural transplants, and surgical or genetic manipulation of cortical development, furnish new details about the kinetics of cell proliferation, their lineage relationships, and phenotypic expression that favor this hypothesis. The radial unit model provides a framework for understanding cerebral evolution, epigenetic regulation of the parcellation of cytoarchitectonic areas, and insight into the pathogenesis of certain cortical disorders in humans.
Similar articles
- Decision by division: making cortical maps.
Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. Rakic P, et al. Trends Neurosci. 2009 May;32(5):291-301. doi: 10.1016/j.tins.2009.01.007. Epub 2009 Apr 18. Trends Neurosci. 2009. PMID: 19380167 Free PMC article. Review. - Experimental manipulation of cerebral cortical areas in primates.
Rakic P. Rakic P. Philos Trans R Soc Lond B Biol Sci. 1991 Mar 29;331(1261):291-4. doi: 10.1098/rstb.1991.0019. Philos Trans R Soc Lond B Biol Sci. 1991. PMID: 1677473 Review. - Postnatal migration of neurons and formation of laminae in rat cerebral cortex.
Ignacio MP, Kimm EJ, Kageyama GH, Yu J, Robertson RT. Ignacio MP, et al. Anat Embryol (Berl). 1995 Feb;191(2):89-100. doi: 10.1007/BF00186782. Anat Embryol (Berl). 1995. PMID: 7726396 - Regulatory mechanisms of cortical laminar development.
Casanova MF, Trippe J 2nd. Casanova MF, et al. Brain Res Rev. 2006 Jun;51(1):72-84. doi: 10.1016/j.brainresrev.2005.10.002. Epub 2005 Dec 15. Brain Res Rev. 2006. PMID: 16359732 Review. - [The development of the human cerebral cortex. A cytoarchitectonic theory].
Marín-Padilla M. Marín-Padilla M. Rev Neurol. 1999 Aug 1-15;29(3):208-16. Rev Neurol. 1999. PMID: 10797903 Review. Spanish.
Cited by
- A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids.
Bosone C, Castaldi D, Burkard TR, Guzman SJ, Wyatt T, Cheroni C, Caporale N, Bajaj S, Bagley JA, Li C, Sorre B, Villa CE, Testa G, Krenn V, Knoblich JA. Bosone C, et al. Nat Methods. 2024 Sep 18. doi: 10.1038/s41592-024-02412-5. Online ahead of print. Nat Methods. 2024. PMID: 39294368 - tubg1 Somatic Mutants Show Tubulinopathy-Associated Neurodevelopmental Phenotypes in a Zebrafish Model.
Cark O, Katkat E, Aydogdu I, Iscan E, Oktay Y, Ozhan G. Cark O, et al. Mol Neurobiol. 2024 Aug 31. doi: 10.1007/s12035-024-04448-2. Online ahead of print. Mol Neurobiol. 2024. PMID: 39215931 - Epigenomic landscapes during prefrontal cortex development and aging in rhesus.
Ning C, Wu X, Zhao X, Lu Z, Yao X, Zhou T, Yi L, Sun Y, Wu S, Liu Z, Huang X, Gao L, Liu J. Ning C, et al. Natl Sci Rev. 2024 Jun 18;11(8):nwae213. doi: 10.1093/nsr/nwae213. eCollection 2024 Aug. Natl Sci Rev. 2024. PMID: 39183748 Free PMC article. - BEAM: A combinatorial recombinase toolbox for binary gene expression and mosaic genetic analysis.
Greig LC, Woodworth MB, Poulopoulos A, Lim S, Macklis JD. Greig LC, et al. Cell Rep. 2024 Aug 27;43(8):114650. doi: 10.1016/j.celrep.2024.114650. Epub 2024 Aug 17. Cell Rep. 2024. PMID: 39159043 Free PMC article. - The Role of 3' Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia.
Guo X, Luo X, Huang X, Zhang Y, Ji J, Wang X, Wang K, Wang J, Pan X, Chen B, Tan Y, Luo X. Guo X, et al. Alpha Psychiatry. 2024 Jun 1;25(3):413-420. doi: 10.5152/alphapsychiatry.2024.241616. eCollection 2024 Jun. Alpha Psychiatry. 2024. PMID: 39148597 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources