Hypoglycemic effects and mechanism of different molecular weights of konjac glucomannans in type 2 diabetic rats - PubMed (original) (raw)
. 2020 Dec 15;165(Pt B):2231-2243.
doi: 10.1016/j.ijbiomac.2020.10.021. Epub 2020 Oct 12.
Jing Zhong 1, Jin Long 2, Xiaoying Zou 1, Da Wang 1, Ya Song 1, Kai Zhou 3, Yuxuan Liang 1, Riming Huang 1, Xiaoqun Wei 1, Meiying Li 4, Yuanming Sun 5
Affiliations
- PMID: 33058981
- DOI: 10.1016/j.ijbiomac.2020.10.021
Hypoglycemic effects and mechanism of different molecular weights of konjac glucomannans in type 2 diabetic rats
Jie Deng et al. Int J Biol Macromol. 2020.
Abstract
Konjac glucomannan (KGM) is a hypoglycemic polysaccharide with a wide range of molecular weights. But study on hypoglycemic effects of KGMs relate to molecular weight is limited. In this study, KGMs with high and medium molecular weights, and the degraded KGMs were analyzed with physicochemical properties, hypoglycemic effects and mechanisms. Results showed that as the molecular weight KGMs decreased, the viscosity decreased, molecular flexibility increased, while chemical groups, crystal structures and main chains showed little change. KGMs with medium molecular weights (KGM-M1, KGM-M2) showed better effects on increasing body weight, decreasing levels of fasting blood glucose, insulin resistance, total cholesterol and low density lipoprotein cholesterol, and enhancing integrity of pancreas and colon, than KGMs with high or low molecular weights (KGM-H, KGM-L) in type 2 diabetic rats. Mechanism analysis suggested that KGM-M1 and KGM-M2 had higher antioxidant and anti-inflammatory activities on elevating superoxide dismutase, decreasing malondialdehyde and tumor necrosis factor-α levels. Moreover, KGM-M1 and KGM-M2 increased gut microbiota diversity, Bacteroidetes/Firmicutes ratio and Muribaculaceae, decreased Romboutsia and Klebsiella, and improved 6 diabetic related metabolites. Combined, KGM-M1 and KGM-M2 showed higher hypoglycemic effects, due to regulatory activities of antioxidant, anti-inflammatory, intestinal microbiota, and relieved metabolic disorders.
Keywords: Hypoglycemic effect; Konjac glucomannan; Molecular weight.
Copyright © 2020 Elsevier B.V. All rights reserved.
Conflict of interest statement
Declaration of competing interest The authors declare that they have no conflict of interests.
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