Vitamin E in Atopic Dermatitis: From Preclinical to Clinical Studies - PubMed (original) (raw)
Review
doi: 10.1159/000510653. Epub 2020 Oct 16.
Affiliations
- PMID: 33070130
- DOI: 10.1159/000510653
Review
Vitamin E in Atopic Dermatitis: From Preclinical to Clinical Studies
Cheryl Wei Ling Teo et al. Dermatology. 2021.
Abstract
Background: Oxidative stress and inflammation are some of the proposed mechanisms involved in the pathogenesis of atopic dermatitis (AD). Current pharmacotherapeutic approaches are effective yet they are not without adverse effects. Vitamin E has great potential as an adjunctive treatment for AD owing to its antioxidant and anti-inflammatory bioactivities.
Summary: This review article summarizes the current available evidence from cellular, animal and clinical studies on the relationship between vitamin E and AD. The future prospects of vitamin E are also discussed. Vitamin E in practice does not show any toxicity to humans within a range of reasonable dosage. Albeit rarely, vitamin E as a contact allergen should be considered. Collectively, this review envisaged vitamin E as an adjunctive treatment for AD patients. Future research on the distinct effects of different vitamin E isoforms as well as their delivery system in skin disorders is needed.
Keywords: Atopic dermatitis; Atopic eczema; Tocopherols; Tocotrienols; Vitamin E.
© 2020 S. Karger AG, Basel.
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