The chicken B cell compartment - PubMed (original) (raw)

Review

. 1987 Nov 20;238(4830):1094-8.

doi: 10.1126/science.3317827.

Affiliations

• PMID: 3317827
• DOI: 10.1126/science.3317827

Review

The chicken B cell compartment

J C Weill et al. Science. 1987.

Abstract

A very unusual molecular mechanism is involved in generating the preimmune repertoire in the chicken bursa of Fabricius. A unique rearranged V gene is diversified through a program of segmental gene conversion with a pool of noncoding pseudogenes being used as donors. A specifically committed progenitor that originates in the embryonic bursa is responsible for long-term maintenance of the B cell population. Both these properties and the characteristics of the peripheral B cell compartment are discussed in terms of the evolution of the T and B immune systems.

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