Effects of selenium supplementation on pregnancy outcomes and disease progression in HIV-infected pregnant women in Lagos: A randomized controlled trial - PubMed (original) (raw)

Randomized Controlled Trial

. 2021 Jun;153(3):533-541.

doi: 10.1002/ijgo.13514. Epub 2021 Jan 5.

Olusola F Olowoselu 3, Sarah John-Olabode 3, Basirat O Hassan 4, Oluwatosin J Akinsola 5, Chidinma M Nwogu 2, Aloy O Ugwu 2, Olusanjo E Moses 6, Kabiru A Rabiu 6, Adegbenga Ajepe 2, Muisi A Adenekan 2, Adebola A Adejimi 5, Sulaimon A Akanmu 3, Phyllis J Kanki 7

Affiliations

• PMID: 33275775
• PMCID: PMC8122028
• DOI: 10.1002/ijgo.13514

Randomized Controlled Trial

Effects of selenium supplementation on pregnancy outcomes and disease progression in HIV-infected pregnant women in Lagos: A randomized controlled trial

Kehinde S Okunade et al. Int J Gynaecol Obstet. 2021 Jun.

Abstract

Objective: To examine the effects of selenium supplementation on pregnancy outcomes and disease progression among HIV-infected pregnant women in Lagos.

Methods: A randomized, placebo-controlled trial conducted among HIV-positive pregnant women between September 2018 and August 2019. At enrollment, 90 women were randomly assigned into each treatment arm to receive either a daily tablet of 200 μg elemental selenium or a placebo. Relevant participants' sociodemographic and clinical data were collected at enrollment and delivery.

Results: Women in the selenium arm had a significantly lower risk of preterm delivery (relative risk [RR] 0.32, 95% confidence interval [CI] 0.11-0.96) and a non-significant reduction in the risk of delivering term neonates with a low delivery weight (RR 0.24, 95% CI 0.05-1.19). Supplemental selenium does not increase the risk of perinatal death and adverse drug events.

Conclusion: The study reported a beneficial effect of prenatal selenium supplements on the risk of preterm delivery with no further reduction in risk among HIV-infected women who used the supplements for more than 14 weeks.

Trial registration: Pan African Clinical Trial Registry (PACTR201809756724274).

Keywords: CD4+ cell count; Lagos; Lagos University Teaching Hospital; low birth weight; preterm delivery; selenium; viral load.

© 2020 International Federation of Gynecology and Obstetrics.

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Conflict of interest statement

CONFLIC TS OF INTEREST

The authors have no conflicts of interest.

Figures

FIGURE 1

Flowchart showing selection of the study population.

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