Ribosomal modification and resistance in antibiotic-producing organisms - PubMed (original) (raw)
Affiliations
- PMID: 3332760
Review
Ribosomal modification and resistance in antibiotic-producing organisms
E Cundliffe. Biochem Soc Symp. 1987.
Abstract
Antibiotic producing organisms defend themselves against their products in a variety of ways including modification of the normal target sites for antibiotic action. In the ribosomal context, some organisms that produce inhibitors of protein synthesis render their own ribosomes refractory to the autogenous drugs via specific methylation of ribosomal RNA. Such hints that antibiotics might normally recognize RNA within the ribosome, complement other data in suggesting that RNA might be intimately associated with--and, in evolutionary terms, might originally have constituted--various functional sites within the ribosome.
Similar articles
- Macrolide antibiotic interaction and resistance on the bacterial ribosome.
Poehlsgaard J, Douthwaite S. Poehlsgaard J, et al. Curr Opin Investig Drugs. 2003 Feb;4(2):140-8. Curr Opin Investig Drugs. 2003. PMID: 12669373 Review. - The mode of action of berninamycin and mechanism of resistance in the producing organism, Streptomyces bernensis.
Thompson J, Cundliffe E, Stark MJ. Thompson J, et al. J Gen Microbiol. 1982 Apr;128(4):875-84. doi: 10.1099/00221287-128-4-875. J Gen Microbiol. 1982. PMID: 6181185 - Species-specific antibiotic-ribosome interactions: implications for drug development.
Wilson DN, Harms JM, Nierhaus KH, Schlünzen F, Fucini P. Wilson DN, et al. Biol Chem. 2005 Dec;386(12):1239-52. doi: 10.1515/BC.2005.141. Biol Chem. 2005. PMID: 16336118 Review. - Drugs targeting the ribosome.
Hermann T. Hermann T. Curr Opin Struct Biol. 2005 Jun;15(3):355-66. doi: 10.1016/j.sbi.2005.05.001. Curr Opin Struct Biol. 2005. PMID: 15919197 Review. - Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance.
Davies C, Bussiere DE, Golden BL, Porter SJ, Ramakrishnan V, White SW. Davies C, et al. J Mol Biol. 1998 Jun 19;279(4):873-88. doi: 10.1006/jmbi.1998.1780. J Mol Biol. 1998. PMID: 9642068
Cited by
- The Seattle Structural Genomics Center for Infectious Disease (SSGCID).
Myler PJ, Stacy R, Stewart L, Staker BL, Van Voorhis WC, Varani G, Buchko GW. Myler PJ, et al. Infect Disord Drug Targets. 2009 Nov;9(5):493-506. doi: 10.2174/187152609789105687. Infect Disord Drug Targets. 2009. PMID: 19594426 Free PMC article. Review. - Expanding the nucleotide repertoire of the ribosome with post-transcriptional modifications.
Chow CS, Lamichhane TN, Mahto SK. Chow CS, et al. ACS Chem Biol. 2007 Sep 21;2(9):610-9. doi: 10.1021/cb7001494. ACS Chem Biol. 2007. PMID: 17894445 Free PMC article. Review. - Ribosomal RNA guanine-(N2)-methyltransferases and their targets.
Sergiev PV, Bogdanov AA, Dontsova OA. Sergiev PV, et al. Nucleic Acids Res. 2007;35(7):2295-301. doi: 10.1093/nar/gkm104. Epub 2007 Mar 27. Nucleic Acids Res. 2007. PMID: 17389639 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical