Association Between Dietary Fiber Intake and Non-alcoholic Fatty Liver Disease in Adults - PubMed (original) (raw)

Association Between Dietary Fiber Intake and Non-alcoholic Fatty Liver Disease in Adults

Huimin Zhao et al. Front Nutr. 2020.

Abstract

Background: Evidence on the association of non-alcoholic fatty liver disease (NAFLD), a public health concern, with dietary fiber intake is inconsistent. Objective: To investigate the relationship between dietary fiber intake from different sources and NAFLD risk in US adults. Methods: Data were collected from the 2007-2014 National Health and Nutrition Examination Survey. NAFLD was defined as a United States Fatty Liver Index ≥30, and dietary fiber intake was assessed through two 24-h dietary recall interviews. Logistic regression and restricted cubic spline models were used to explore the relationship of dietary intakes of total, cereal, fruit, and vegetable fiber with NAFLD risk. Results: A total of 6,613 participants, aged more than 20 years, were included in this study. After adjusting for multiple confounding factors, the odds ratios and 95% confidence intervals of NAFLD for the highest quartile vs. lowest quartile intakes of total, cereal, fruit, and vegetable fiber were 0.12 (0.08-0.16), 0.25 (0.19-0.33), 0.41 (0.33-0.52), and 0.42 (0.32-0.56), respectively. In stratified analyses by sex and age, statistically significant negative associations of dietary intakes of total, cereal, fruit, and vegetable fiber with NAFLD risk were observed in all participants. Dose-response analysis indicated a non-linear correlation between NAFLD risk and dietary intake of total fiber, whereas the relationship was linear for cereal, fruit, and vegetable fiber intakes. Conclusion: Total, cereal, fruit, and vegetable fiber intakes exhibit negative correlations with NAFLD risk in the general adult population in the United States.

Keywords: National Health and Nutrition Examination Survey (NHANES); Non-alcoholic fatty liver disease (NAFLD); cereal fiber; dietary intake; dose-response; fruit fiber; vegetable fiber.

Copyright © 2020 Zhao, Yang, Mao, Quan, Cui and Sun.

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Figures

Figure 1

Figure 1

Flow chart of the selection process. NHANES, National Health and Nutrition Examination Survey.

Figure 2

Figure 2

The restricted cubic spline model showed a dose-response relationship between total, cereal, fruit and vegetable dietary fiber intake per kilogram of body weight per day and NAFLD. The lowest level of total fiber intake (38 mg/kg/day), cereal fiber intake (4 mg/kg/day), fruit fiber intake (0 mg/kg/day) and vegetable fiber intake (0 mg/kg/day) were used as the reference group, respectively. Adjustments were made according to age, sex, race, education level, smoking status, income level, hypertension, diabetes, vigorous recreational activity, average energy intake, UA and TC. The solid line and the dotted line represent the estimated OR and the corresponding 95%CI, respectively. OR, odds ratio.

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