Stable improvement in classical B-cell chronic lymphocytic leukemia with dietary interventions: A personal experience - PubMed (original) (raw)

Case Reports

. 2020 Sep 14;8(12):2948-2954.

doi: 10.1002/ccr3.3305. eCollection 2020 Dec.

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Case Reports

Stable improvement in classical B-cell chronic lymphocytic leukemia with dietary interventions: A personal experience

Frans X Plooij et al. Clin Case Rep. 2020.

Abstract

If the lymphocyte count is still low enough, the first part of the wait-and-see approach for asymptomatic Rai stage 0 classical B-CLL can be used to find out if the lymphocyte counts follow an exponential growth curve. If they do, the whole food, plant-based (WFPB) diet intervention can be started.

Keywords: B‐CLL; dietary intervention; hematology; lifestyle medicine; oncology; plant‐based diet; whole food.

© 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

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Conflict of interest statement

None declared.

Figures

Figure 1

Figure 1

Course of disease related to three dietary interventions. The remarkably consistent and stable reversal of the progressive CLL co‐occurring with a sharp decrease in body weight (gray line) after starting the Flexitarian diet (yellow box) followed by the Whole Food Plant‐Based (WFPB) diet intervention (blue box). Initially, the leukocytes (blue dots) follow an exponential growth curve that is depicted by the black, broken line fitted through the first 5 measurements and extrapolated; y = 13.401e0,0057 x; R 2 = .9919). (Note: In week 0, no lymphocyte count was available in the hospital records. Therefore, the leukocyte counts were used for fitting and extrapolating the exponential growth curve. This is considered a good proxi since the lymphocyte counts tend to follow the leukocyte counts, albeit a little lower). The epigallocatechin gallate (EGCG) therapy (pink box) had no effect whatsoever: the leukocyte (blue dots) and lymphocyte (red dots) counts did not deviate from the extrapolated curve. After the reversal of the progressive CLL, the lymphocyte counts (red dots) stabilized around a mean of 41 × 109/L (SD = 5). A linear trend with a slightly downward slope (see the red, dotted line; y = −0.0118_x_ + 46.623; R 2 = .0293) was fitted through the lymphocyte counts following the reversal. The body weight curve (gray line) depicts a moving average of onethird of the measurement points

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