Actin filaments, stereocilia, and hair cells of the bird cochlea. V. How the staircase pattern of stereociliary lengths is generated - PubMed (original) (raw)

Actin filaments, stereocilia, and hair cells of the bird cochlea. V. How the staircase pattern of stereociliary lengths is generated

L G Tilney et al. J Cell Biol. 1988 Feb.

Abstract

The stereocilia on each hair cell are arranged into rows of ascending height, resulting in what we refer to as a "staircase-like" profile. At the proximal end of the cochlea the length of the tallest row of stereocilia in the staircase is 1.5 micron, with the shortest row only 0.3 micron. As one proceeds towards the distal end of the cochlea the length of the stereocilia progressively increases so that at the extreme distal end the length of the tallest row of the staircase is 5.5 micron and the shortest row is 2 micron. During development hair cells form their staircases in four phases of growth separated from each other by developmental time. First, stereocilia sprout from the apical surfaces of the hair cells (8-10-d embryos). Second (10-12-d embryos), what will be the longest row of the staircase begins to elongate. As the embryo gets older successive rows of stereocilia initiate elongation. Thus the staircase is set up by the sequential initiation of elongation of stereociliary rows located at increased distances from the row that began elongation. Third (12-17-d embryos), all the stereocilia in the newly formed staircase elongate until those located on the first step of the staircase have reached the prescribed length. In the final phase (17-d embryos to hatchlings) there is a progressive cessation of elongation beginning with the shortest step and followed by taller and taller rows with the tallest step stopping last. Thus, to obtain a pattern of stereocilia in rows of increasing height what transpires are progressive go signals followed by a period when all the stereocilia grow and ending with progressive stop signals. We discuss how such a sequence could be controlled.

PubMed Disclaimer

Cited by

A Biophysical Model for the Staircase Geometry of Stereocilia.
Orly G, Manor U, Gov NS. Orly G, et al. PLoS One. 2015 Jul 24;10(7):e0127926. doi: 10.1371/journal.pone.0127926. eCollection 2015. PLoS One. 2015. PMID: 26207893 Free PMC article.
The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.
Pepermans E, Michel V, Goodyear R, Bonnet C, Abdi S, Dupont T, Gherbi S, Holder M, Makrelouf M, Hardelin JP, Marlin S, Zenati A, Richardson G, Avan P, Bahloul A, Petit C. Pepermans E, et al. EMBO Mol Med. 2014 Jul;6(7):984-92. doi: 10.15252/emmm.201403976. EMBO Mol Med. 2014. PMID: 24940003 Free PMC article.
Hair bundle profiles along the chick basilar papilla.
Duncan RK, Ile KE, Dubin MG, Saunders JC. Duncan RK, et al. J Anat. 2001 Jan;198(Pt 1):103-16. doi: 10.1046/j.1469-7580.2001.19810103.x. J Anat. 2001. PMID: 11215761 Free PMC article.
Regulation of actin-based apical structures on epithelial cells.
Pelaseyed T, Bretscher A. Pelaseyed T, et al. J Cell Sci. 2018 Oct 17;131(20):jcs221853. doi: 10.1242/jcs.221853. J Cell Sci. 2018. PMID: 30333133 Free PMC article. Review.
Transcriptional Dynamics of Hair-Bundle Morphogenesis Revealed with CellTrails.
Ellwanger DC, Scheibinger M, Dumont RA, Barr-Gillespie PG, Heller S. Ellwanger DC, et al. Cell Rep. 2018 Jun 5;23(10):2901-2914.e13. doi: 10.1016/j.celrep.2018.05.002. Cell Rep. 2018. PMID: 29874578 Free PMC article.

References

1. J Biol Chem. 1986 Oct 25;261(30):14191-5 - PubMed
1. Annu Rev Biochem. 1986;55:987-1035 - PubMed
1. Biochemistry. 1980 Jun 10;19(12):2677-83 - PubMed
1. Hear Res. 1987;25(2-3):141-51 - PubMed
1. Hear Res. 1987;26(1):45-64 - PubMed

Actin filaments, stereocilia, and hair cells of the bird cochlea. V. How the staircase pattern of stereociliary lengths is generated - PubMed (original) (raw)