5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue - PubMed (original) (raw)

5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue

S V Cannon et al. Biochem Biophys Res Commun. 1988.

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Abstract

The enzymatic release of 5-hydroxymethylcytosine from T2 bacteriophage DNA was effected by an extract of calf thymus. Like the previously described 5-hydroxymethyluracil DNA glycosylase, 5-hydroxymethylcytosine DNA glycosylase was not detectable in bacterial extracts. The phylogenetic distribution of these activities indicates that their primary function is the maintenance of methylcytosine residues in differentiated tissue.

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