Perioperative suppression of platelet adherence to small-diameter polytetrafluoroethylene (PTFE) grafts - PubMed (original) (raw)
Perioperative suppression of platelet adherence to small-diameter polytetrafluoroethylene (PTFE) grafts
R M Fujitani et al. J Surg Res. 1988 Apr.
Abstract
The perioperative effect of platelet antagonists on small-diameter polytetrafluoroethylene (PTFE) grafts was evaluated in forty-six New Zealand white male rabbits receiving either dipyridamole (DPM) 100 mg/kg/day (n = 10; group 1), aspirin (ASA) 10 mg/kg/day (n = 10; group 2), a combination of ASA 10 mg/kg/day and DPM 10 mg/kg/day (n = 9; group 3) or 100 mg/kg/day (n = 10; group 4), or placebo (n = 7) as single daily doses. All regimens began 72 hr prior to insertion of a 20 x 3-mm internal diameter PTFE interposition aortic graft. Autologous indium-111 labeled platelets were injected immediately after implantation. Graft and an equivalent segment of aorta were harvested after 48 hr. Graft platelet adherence index (GPAI) was calculated as the graft:reference aorta ratio of emissions. The GPAI in the control group was 238 +/- 46 (mean +/- SD). Single regimen antiplatelet agents in groups 1 and 2 reduced mean GPAI to 47 +/- 38 and 40 +/- 12, respectively. The combination regimen in group 3 lowered mean GPAI to 43 +/- 8 and in group 4 to 21 +/- 7. Platelet uptake in PTFE grafts at 48 hr is significantly lowered to 8.8 to 19.7% of control by perioperative antiplatelet agents given as a single daily oral dose (P less than 0.001). ASA alone and DPM alone provided similar suppression of platelet uptake, but combination ASA + low dose or high dose DPM gave significantly greater (P less than 0.001) suppression of early platelet deposition than the single agent regimens. These results support perioperative administration of combination oral antiplatelet agents as adjunctive therapy in small diameter prosthetic graft implantation.
Similar articles
- Platelet antagonists eliminate thromboembolic complications of small-diameter arterial prostheses.
Nordestgaard AG, Buckels JA, Wilson SE. Nordestgaard AG, et al. J Vasc Surg. 1987 Jan;5(1):110-7. J Vasc Surg. 1987. PMID: 3795377 - Effect of Aspirin and Dipyridamole on Sequential Graft Platelet Accumulation after Implantation of Small Diameter PTFE Prosthesis.
Nordestgaard AG, Marcus CS, Wilson SE. Nordestgaard AG, et al. Platelets. 1990;1(1):37-41. doi: 10.3109/09537109009009194. Platelets. 1990. PMID: 21043984 - Radionuclide study of platelets and prosthetic interactions: external versus specimen quantitation.
Nordestgaard AG, Marcus CS, Wilson SE. Nordestgaard AG, et al. J Invest Surg. 1988;1(1):28-34. doi: 10.3109/08941938809141073. J Invest Surg. 1988. PMID: 3154077 - Ticlopidine versus aspirin and dipyridamole: influence on platelet deposition and three-month patency of polytetrafluoroethylene grafts.
Hansen KJ, Howe HR, Edgerton TA, Faust KB, Kon ND, Geisinger KR, Meredith JH. Hansen KJ, et al. J Vasc Surg. 1986 Aug;4(2):174-8. doi: 10.1067/mva.1986.avs0040174. J Vasc Surg. 1986. PMID: 3735571
Cited by
- Antiplatelet agents for preventing thrombosis after peripheral arterial bypass surgery.
Bedenis R, Lethaby A, Maxwell H, Acosta S, Prins MH. Bedenis R, et al. Cochrane Database Syst Rev. 2015 Feb 19;2015(2):CD000535. doi: 10.1002/14651858.CD000535.pub3. Cochrane Database Syst Rev. 2015. PMID: 25695213 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical