The incidence trends of liver cirrhosis caused by nonalcoholic steatohepatitis via the GBD study 2017 - PubMed (original) (raw)

Mimi Zhai et al. Sci Rep. 2021.

Abstract

Nonalcoholic steatohepatitis (NASH) has rapidly become the most common cause of chronic liver diseases. We aimed to explore the incidence and distribution characteristics of NASH by sex, region and sociodemographic index (SDI). We collected data, including sex and region, on NASH-related liver cirrhosis from the 2017 GBD study. The age-standardized incidence rates (ASRs) and estimated annual percentage changes (EAPCs) were used to estimate the incidence trend and distribution characteristics. Globally, the incidence of liver cirrhosis caused by NASH increased from 178,430 cases in 1990 to 367,780 cases in 2017, an increase of approximately 105.56%. The ASR of NASH increased by an average of 1.35% per year (95% CI 1.28-1.42). Meanwhile, large differences in the ASR and the EAPC were observed across regions. The middle-high SDI region had the highest increase among all five SDI regions, followed by middle SDI region. In addition, Eastern Europe, Andean Latin America and Central Asia showed a more significant growth trend of ASR. In contrast, the high SDI region demonstrated the slowest increasing trend of ASR, and the high-income Asia Pacific demonstrated a decreasing trend among the 21 regions. Liver cirrhosis has caused a huge and rising health burden in many countries and regions. In addition, with the growth of obesity, population and aging, NASH might replace viral hepatitis as the most important cause of liver cirrhosis in the near future. Therefore, appropriate interventions are needed in coming decades to realize early diagnosis and prevention of NASH-related liver cirrhosis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1

Figure 1

The overall incident cases of liver cirrhosis caused by NASH in 195 countries and territories. (A) The incident cases in 1990 across the world. (B) The incident cases in 2017 across the world. (C) The change in incident cases of liver cirrhosis caused by NASH from 1990 to 2017 across the world. Figures were created by STATA/MP 13.1 software. The SHP data of the world map were converted to STATA data via the “shp2dta” command, and maps were drawn via the “spmap” command after incorporating variables.

Figure 2

Figure 2

The global burden of liver cirrhosis incidence caused by NASH in 195 countries and territories. (A) The ASR of liver cirrhosis incidence caused by NASH in 1990. (B) The ASR of liver cirrhosis incidence caused by NASH in 2017. (C) The ASR trend of liver cirrhosis caused by NASH from 1990 to 2017 across the world. Figures were created via the method mentioned in Fig. 1.

Figure 3

Figure 3

Liver cirrhosis incident cases caused by NASH and SDI regions from 1990 to 2017. Figures were created by STATA/MP 13.1 software. The bar charts were drawn via the “graph bar” command, and the cumulative bar charts were drawn by adding the option “stack”.

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